Regulation of iron homeostasis by microRNAs

• Verfasst von: Castoldi, Mirco [VerfasserIn]
• Verfasst von: Muckenthaler, Martina [VerfasserIn]
• Titel: Regulation of iron homeostasis by microRNAs
• Verf.angabe: Mirco Castoldi, Martina U. Muckenthaler
• Umfang: 8 S.
• Fussnoten: Gesehen am 03.05.2018
• Titel Quelle: Enthalten in: Cellular and molecular life sciences
• Jahr Quelle: 2012
• Band/Heft Quelle: 69(2012), 23, S. 3945-3952
• ISSN Quelle: 1420-9071
• DOI: doi:10.1007/s00018-012-1031-4
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 157257464X

Abstract

Iron homeostasis is maintained at the cellular and systemic levels to assure adequate iron supply while preventing iron overload. The identification of genes mutated in patients with iron-related disorders or animal models with imbalances of iron homeostasis gave insight into the molecular mechanisms underlying processes critical for balancing iron levels, such as iron uptake, storage, export, and monitoring of available iron. MicroRNAs control genes involved in some of these processes adding an additional level of complexity to the regulation of iron metabolism. This review summarizes recent advances how miRNAs regulate iron homeostasis.