Local complement activation in aqueous humor in patients with age-related macular degeneration

• Verfasst von: Schick, Tina [VerfasserIn]
• Verfasst von: Kirschfink, Michael [VerfasserIn]
• Titel: Local complement activation in aqueous humor in patients with age-related macular degeneration
• Verf.angabe: T Schick, M Steinhauer, A Aslanidis, L Altay, M Karlstetter, T Langmann, M Kirschfink and S Fauser
• Umfang: 4 S.
• Fussnoten: Gesehen am 03.05.2018
• Titel Quelle: Enthalten in: Eye
• Jahr Quelle: 2017
• Band/Heft Quelle: 31(2017), 5, S. 810-813
• ISSN Quelle: 1476-5454
• DOI: doi:10.1038/eye.2016.328
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 157257805X

Abstract

Purpose: To investigate complement activation in aqueous humor and in plasma of patients with neovascular age-related macular degeneration (nAMD). Patients and methods: Aqueous humor and EDTA-plasma of 31 nAMD patients and 30 age-matched controls was collected. The levels of the complement factor 3 (C3), the regulators factor H (FH), and factor I (FI), and of the complement activation products Ba, C3a, and the terminal complement complex (sC5b-9) were measured. Associations between complement levels and phenotype were determined using Mann-Whitney U-test. Results: In plasma, no significant differences were found between the nAMD group and the control group. In aqueous humor, significantly increased levels of Ba (P=0.002), and C3a (P=0.002) indicate local complement activation in nAMD patients and a trend for a concomitant upregulation of the complement regulators FH (P=0.02) and FI (P=0.04). Conclusions: Our findings provide strong evidence for a local complement dysregulation in nAMD patients.