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Verfasst von:Thome, Janine [VerfasserIn]   i
 Hauschild, Sophie [VerfasserIn]   i
 Koppe, Georgia [VerfasserIn]   i
 Schmahl, Christian [VerfasserIn]   i
 Bohus, Martin [VerfasserIn]   i
Titel:Generalisation of fear in PTSD related to prolonged childhood maltreatment
Titelzusatz:an experimental study
Verf.angabe:Janine Thome, Sophie Hauschild, Georgia Koppe, Lisa Liebke, Sophie Rausch, Julia I. Herzog, Meike Müller-Engelmann, Regina Steil, Kathlen Priebe, Dirk Hermans, Christian Schmahl, Martin Bohus and Stefanie Lis
Jahr:2018
Umfang:12 S.
Fussnoten:Gesehen am 05.11.2018 ; Article was first published online on 28 December 2017
Titel Quelle:Enthalten in: Psychological medicine
Ort Quelle:Cambridge : Cambridge University Press, 1970
Jahr Quelle:2018
Band/Heft Quelle:48(2018), 13, Seite 2223-2234
ISSN Quelle:1469-8978
Abstract:BACKGROUND: Fear responses are particularly intense and persistent in post-traumatic stress disorder (PTSD), and can be evoked by unspecific cues that resemble the original traumatic event. Overgeneralisation of fear might be one of the underlying mechanisms. We investigated the generalisation and discrimination of fear in individuals with and without PTSD related to prolonged childhood maltreatment. METHODS: Sixty trauma-exposed women with (N = 30) and without (N = 30) PTSD and 30 healthy control participants (HC) underwent a fear conditioning and generalisation paradigm. In a contingency learning procedure, one of two circles of different sizes was associated with an electrical shock (danger cue), while the other circle represented a safety cue. During generalisation testing, online risk ratings, reaction times and fear-potentiated startle were measured in response to safety and danger cues as well as to eight generalisation stimuli, i.e. circles of parametrically varying size creating a continuum of similarity between the danger and safety cue. RESULTS: The increase in reaction times from the safety cue across the different generalisation classes to the danger cue was less pronounced in PTSD compared with HC. Moreover, PTSD participants expected higher risk of an aversive event independent of stimulus types and task. CONCLUSIONS: Alterations in generalisation constitute one part of fear memory alterations in PTSD. Neither the accuracy of a risk judgement nor the strength of the induced fear was affected. Instead, processing times as an index of uncertainty during risk judgements suggested a reduced differentiation between safety and threat in PTSD.
DOI:doi:10.1017/S0033291717003713
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1017/S0033291717003713
 DOI: https://doi.org/10.1017/S0033291717003713
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:classical conditioning
 early life maltreatment
 fear generalisation
 fear-potentiated startle
 interpersonal violence
 post-traumatic stress disorder
 safety signals
K10plus-PPN:1572582332
Verknüpfungen:→ Zeitschrift

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