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Verfasst von:Packer, Roger J. [VerfasserIn]   i
 Pfister, Stefan [VerfasserIn]   i
 Witt, Olaf [VerfasserIn]   i
Titel:Pediatric low-grade gliomas
Titelzusatz:implications of the biologic era
Verf.angabe:Roger J. Packer, Stephan Pfister, Olaf Witt
Umfang:12 S.
Fussnoten:Gesehen am 03.05.2018
Titel Quelle:Enthalten in: Neuro-Oncology
Jahr Quelle:2017
Band/Heft Quelle:19(2017), 6, S. 750-761
ISSN Quelle:1523-5866
Abstract:For the past decade, it has been recognized that pediatric low-grade gliomas (LGGs) and glial-neuronal tumors carry distinct molecular alterations with resultant aberrant intracellular signaling in the Ras-mitogen-activated protein kinase pathway. The conclusions and recommendations of a consensus conference of how best to integrate the growing body of molecular genetic information into tumor classifications and, more importantly, for future treatment of pediatric LGGs are summarized here. There is uniform agreement that molecular characterization must be incorporated into classification and is increasingly critical for appropriate management. Molecular-targeted therapies should be integrated expeditiously, but also carefully into the management of these tumors and success measured not only by radiographic responses or stability, but also by functional outcomes. These trials need to be carried out with the caveat that the long-term impact of molecularly targeted therapy on the developing nervous system, especially with long duration treatment, is essentially unknown.
DOI:doi:10.1093/neuonc/now209
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Verlag: http://dx.doi.org/10.1093/neuonc/now209
 Verlag: https://academic.oup.com/neuro-oncology/article/19/6/750/3057258
 DOI: https://doi.org/10.1093/neuonc/now209
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1572590009
Verknüpfungen:→ Zeitschrift

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