Ki-67 expression predicts radiosensitivity in oral squamous cell carcinoma

• Verfasst von: Freudlsperger, Christian [VerfasserIn]
• Verfasst von: Freier, Kolja [VerfasserIn]
• Verfasst von: Hoffmann, Jürgen [VerfasserIn]
• Verfasst von: Engel, Michael [VerfasserIn]
• Titel: Ki-67 expression predicts radiosensitivity in oral squamous cell carcinoma
• Verf.angabe: C. Freudlsperger, K. Freier, J. Hoffmann, M. Engel
• Umfang: 5 S.
• Fussnoten: Gesehen am 03.05.2018
• Titel Quelle: Enthalten in: International journal of oral and maxillofacial surgery
• Jahr Quelle: 2012
• Band/Heft Quelle: 41(2012), 8, S. 965-969
• ISSN Quelle: 1399-0020
• DOI: doi:10.1016/j.ijom.2012.04.014
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1572605847

Abstract

The prognostic relevance of Ki-67 expression in oral squamous cell carcinoma (OSCC) is still controversial. As proliferating cells are more susceptible to ionizing radiation, the authors investigated if a high proliferation rate reflected by Ki-67 expression, predicts radiosensitivity in OSCC patients. In 52 patients with OSCC who received primary surgery followed by radiation therapy, the proliferation rate was assessed by Ki-67 immunhistochemistry and correlated to recurrent free survival and overall survival. Low proliferative carcinomas showed a significantly shorter mean time to recurrence of 27.5 months compared to 49.5 months of high proliferative tumours (p=0.048). The 5-year survival rate of low proliferative tumours was 49% compared to 80% for high proliferative tumours (p=0.042). This study indicates that tumours with high proliferative activity are more susceptible to radiation therapy. Ki-67 might be used as a marker to predict the response to radiation therapy in patients with OSCC.