Status: Bibliographieeintrag
Standort: ---
Exemplare:
---
| Online-Ressource |
Verfasst von: | Freudlsperger, Christian [VerfasserIn]  |
| Freier, Kolja [VerfasserIn]  |
| Hoffmann, Jürgen [VerfasserIn]  |
| Engel, Michael [VerfasserIn]  |
Titel: | Ki-67 expression predicts radiosensitivity in oral squamous cell carcinoma |
Verf.angabe: | C. Freudlsperger, K. Freier, J. Hoffmann, M. Engel |
Umfang: | 5 S. |
Fussnoten: | Gesehen am 03.05.2018 |
Titel Quelle: | Enthalten in: International journal of oral and maxillofacial surgery |
Jahr Quelle: | 2012 |
Band/Heft Quelle: | 41(2012), 8, S. 965-969 |
ISSN Quelle: | 1399-0020 |
Abstract: | The prognostic relevance of Ki-67 expression in oral squamous cell carcinoma (OSCC) is still controversial. As proliferating cells are more susceptible to ionizing radiation, the authors investigated if a high proliferation rate reflected by Ki-67 expression, predicts radiosensitivity in OSCC patients. In 52 patients with OSCC who received primary surgery followed by radiation therapy, the proliferation rate was assessed by Ki-67 immunhistochemistry and correlated to recurrent free survival and overall survival. Low proliferative carcinomas showed a significantly shorter mean time to recurrence of 27.5 months compared to 49.5 months of high proliferative tumours (p=0.048). The 5-year survival rate of low proliferative tumours was 49% compared to 80% for high proliferative tumours (p=0.042). This study indicates that tumours with high proliferative activity are more susceptible to radiation therapy. Ki-67 might be used as a marker to predict the response to radiation therapy in patients with OSCC. |
DOI: | doi:10.1016/j.ijom.2012.04.014 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Verlag: http://dx.doi.org/10.1016/j.ijom.2012.04.014 |
| Verlag: http://www.sciencedirect.com/science/article/pii/S0901502712001695 |
| DOI: https://doi.org/10.1016/j.ijom.2012.04.014 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1572605847 |
Verknüpfungen: | → Zeitschrift |
Ki-67 expression predicts radiosensitivity in oral squamous cell carcinoma / Freudlsperger, Christian [VerfasserIn] (Online-Ressource)
68248948