Plasmacytoid dendritic cells control B cell-derived IL-10 production

• Verfasst von: Georg, Philipp [VerfasserIn]
• Verfasst von: Bekeredjian-Ding, Isabelle [VerfasserIn]
• Titel: Plasmacytoid dendritic cells control B cell-derived IL-10 production
• Verf.angabe: Philipp Georg & Isabelle Bekeredjian-Ding
• E-Jahr: 2012
• Jahr: 17 Sep 2012
• Umfang: 5 S.
• Fussnoten: Gesehen am 04.05.2018
• Titel Quelle: Enthalten in: Autoimmunity
• Ort Quelle: Abingdon : Taylor & Francis Group, 1988
• Jahr Quelle: 2012
• Band/Heft Quelle: 45(2012), 8, Seite 579-583
• ISSN Quelle: 1607-842X
• DOI: doi:10.3109/08916934.2012.719955
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: B regulatory cells
• Sach-SW: IL-10
• Sach-SW: plasmacytoid dendritic cells
• Sach-SW: TLR
• Sach-SW: tolerance
• K10plus-PPN: 1572631562

Abstract

Plasmacytoid dendritic cells (pDC) exert contradictory roles: they represent major players in the pathogenesis of type I interferon-mediated autoimmunity but contribute to tolerance in the transplant setting. In this study we describe pDC as cellular enhancers of B cell-derived IL-10 production, a mechanism recently described as relevant in maintaining peripheral tolerance. Our data demonstrate that in human peripheral blood pDC augment IL-10 production in B cells in response to TLR7 and -9 ligands. They further show that pDC themselves produce IL-10 in response to TLR stimulation, most prominently after triggering of TLR7. Additionally, the data indicate that the positive regulatory effect of pDC on IL-10 production is not due to type I interferon production or other soluble factors. We conclude that pDC/B cell contact is essential for B cell-mediated immune suppression.