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Verfasst von:Aksay, Suna Su [VerfasserIn]   i
 Janke, Christoph [VerfasserIn]   i
 Sartorius, Alexander [VerfasserIn]   i
Titel:Alcohol use disorder as a possible predictor of electroconvulsive therapy response
Verf.angabe:Suna Su Aksay, Melanie Hambsch, Christoph Janke, Jan Malte Bumb, Laura Kranaster, Alexander Sartorius
E-Jahr:2017
Jahr:Jun 2017
Umfang:5 S.
Fussnoten:Gesehen am 04.05.2018
Titel Quelle:Enthalten in: The journal of ECT
Ort Quelle:Philadelphia, Pa. : Lippincott Williams & Wilkins, 1998
Jahr Quelle:2017
Band/Heft Quelle:33(2017), 2, Seite 117-121
ISSN Quelle:1533-4112
Abstract:Two rapidly acting antidepressive treatment forms, namely, electroconvulsive therapy (ECT) and ketamine, possibly share a common mechanism of action primarily involving alterations of neurotransmission (glutamate and γ-aminobutyric acid levels). Because patients receiving ketamine and with a coexistent family history of an alcohol use disorder (AUD) seem to benefit from consistent and longer lasting antidepressive effects, we hypothesized better treatment response in ECT patients with an own history or a family history of an AUD. One hundred forty-one psychiatric inpatients with a major depressive episode, who were treated with ECT, were enrolled into this retrospective study. Age, sex, family or personal history of alcohol or benzodiazepine use disorder, ECT response data, and ECT treatment-related data were collected and analyzed with ordinal logistic regression and Fisher exact tests. Twenty-one percent of all patients had their own history of an AUD, 11% had their own history of a benzodiazepine use disorder, and 11% reported on a positive family history of alcohol or benzodiazepine use disorder. The logistic regression analyses revealed that only patient's own history of an AUD predicts a better ECT response (P = 0.031; odds ratio, 2.1; Fisher exact test, P = 0.006). Within the limitations of a retrospective study, a history of an AUD seems to be a positive predictor for an ECT response in patients experiencing a major depressive episode, which has not been found in 2 earlier studies. Findings are in line with neurobiological hypotheses of excitatory/inhibitory neurotransmitter changes with ketamine and ECT.
DOI:doi:10.1097/YCT.0000000000000366
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1097/YCT.0000000000000366
 Volltext: https://insights-ovid-com.ezproxy.medma.uni-heidelberg.de/crossref?an=00124509-201706000-00008
 DOI: https://doi.org/10.1097/YCT.0000000000000366
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1572638125
Verknüpfungen:→ Zeitschrift

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