| |  Online-Ressource |
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| Verfasst von: | Morath, Christian [VerfasserIn]  |
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| | Schmitt, Anita [VerfasserIn] |
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| | Kälble, Florian [VerfasserIn] |
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| | Zeier, Martin [VerfasserIn] |
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| | Schmitt, Michael [VerfasserIn] |
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| | Şandra-Petrescu, Flavius Ionuţ [VerfasserIn] |
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| | Opelz, Gerhard [VerfasserIn] |
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| | Terness, Peter [VerfasserIn] |
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| | Schaier, Matthias [VerfasserIn] |
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| | Kleist, Christian [VerfasserIn] |
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| Titel: | Cell therapeutic approaches to immunosuppression after clinical kidney transplantation |
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| Verf.angabe: | Christian Morath, Anita Schmitt, Florian Kälble, Martin Zeier, Michael Schmitt, Flavius Sandra-Petrescu, Gerhard Opelz, Peter Terness, Matthias Schaier, Christian Kleist |
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| Jahr: | 2018 |
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| Jahr des Originals: | 2017 |
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| Umfang: | 15 S. |
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| Fussnoten: | Published online: 23 February 2017 ; Gesehen am 07.05.2018 |
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| Titel Quelle: | Enthalten in: Pediatric nephrology |
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| Ort Quelle: | Berlin : Springer, 1987 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 33(2018), 2, Seite 199-213 |
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| ISSN Quelle: | 1432-198X |
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| Abstract: | Refinement of immunosuppressive strategies has led to further improvement of kidney graft survival in recent years. Currently, the main limitations to long-term graft survival are life-threatening side effects of immunosuppression and chronic allograft injury, emphasizing the need for innovative immunosuppressive regimens that resolve this therapeutic dilemma. Several cell therapeutic approaches to immunosuppression and donor-specific unresponsiveness have been tested in early phase I and phase II clinical trials in kidney transplantation. The aim of this overview is to summarize current cell therapeutic approaches to immunosuppression in clinical kidney transplantation with a focus on myeloid suppressor cell therapy by mitomycin C-induced cells (MICs). MICs show great promise as a therapeutic agent to achieve the rapid and durable establishment of donor-unresponsiveness in living-donor kidney transplantation. Cell-based therapeutic approaches may eventually revolutionize immunosuppression in kidney transplantation in the near future. |
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| DOI: | doi:10.1007/s00467-017-3599-2 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1007/s00467-017-3599-2 |
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| | Volltext: https://link.springer.com/article/10.1007/s00467-017-3599-2 |
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| | DOI: https://doi.org/10.1007/s00467-017-3599-2 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1574011359 |
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| Verknüpfungen: | → Zeitschrift |
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Cell therapeutic approaches to immunosuppression after clinical kidney transplantation / Morath, Christian [VerfasserIn]; 2018 (Online-Ressource)
