Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Altendorfer, Mario [VerfasserIn]  |
Titel: | Modular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes |
Verf.angabe: | Mario Altendorfer, Aruna Raja, Florenz Sasse, Herbert Irschik and Dirk Menche |
Jahr: | 2013 |
Jahr des Originals: | 2012 |
Umfang: | 24 S. |
Teil: | volume:11 |
| year:2013 |
| number:13 |
| pages:2116-2139 |
| extent:24 |
Fussnoten: | Published online: 19 November 2012 ; Gesehen am 08.05.2018 |
Titel Quelle: | Enthalten in: Organic & biomolecular chemistry |
Ort Quelle: | Cambridge : Royal Society of Chemistry, 2003 |
Jahr Quelle: | 2013 |
Band/Heft Quelle: | 11(2013), 13, Seite 2116-2139 |
ISSN Quelle: | 1477-0539 |
Abstract: | An efficient procedure for the concise synthesis of hetero-bis-metallated alkenes as useful building blocks for the modular access to highly elaborate polyenes and stabilized analogues is reported. By applying these bifunctional olefins in convergent Stille/Suzuki-Miyaura couplings, novel, carefully selected side chain analogues of the potent RNA polymerase inhibitor etnangien were synthesized by a modular late stage coupling strategy and evaluated for antibacterial and antiproliferative activities. |
DOI: | doi:10.1039/c2ob26906f |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1039/c2ob26906f |
| DOI: https://doi.org/10.1039/c2ob26906f |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Alkenes |
| Animals |
| Anti-Bacterial Agents |
| Bacillus subtilis |
| Cell Proliferation |
| Cells, Cultured |
| Corynebacterium |
| DNA-Directed RNA Polymerases |
| Dose-Response Relationship, Drug |
| Enzyme Inhibitors |
| Fibroblasts |
| Macrolides |
| Mice |
| Microbial Sensitivity Tests |
| Molecular Structure |
| Organometallic Compounds |
| Polyenes |
| Structure-Activity Relationship |
K10plus-PPN: | 1574258052 |
Verknüpfungen: | → Zeitschrift |
Modular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes / Altendorfer, Mario [VerfasserIn]; 2013 (Online-Ressource)
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