Status: Bibliographieeintrag
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| Verfasst von: | Altendorfer, Mario [VerfasserIn]  |
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| Titel: | Modular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes |
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| Verf.angabe: | Mario Altendorfer, Aruna Raja, Florenz Sasse, Herbert Irschik and Dirk Menche |
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| Jahr: | 2013 |
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| Jahr des Originals: | 2012 |
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| Umfang: | 24 S. |
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| Teil: | volume:11 |
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| | year:2013 |
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| | number:13 |
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| | pages:2116-2139 |
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| | extent:24 |
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| Fussnoten: | Published online: 19 November 2012 ; Gesehen am 08.05.2018 |
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| Titel Quelle: | Enthalten in: Organic & biomolecular chemistry |
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| Ort Quelle: | Cambridge : Royal Society of Chemistry, 2003 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 11(2013), 13, Seite 2116-2139 |
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| ISSN Quelle: | 1477-0539 |
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| Abstract: | An efficient procedure for the concise synthesis of hetero-bis-metallated alkenes as useful building blocks for the modular access to highly elaborate polyenes and stabilized analogues is reported. By applying these bifunctional olefins in convergent Stille/Suzuki-Miyaura couplings, novel, carefully selected side chain analogues of the potent RNA polymerase inhibitor etnangien were synthesized by a modular late stage coupling strategy and evaluated for antibacterial and antiproliferative activities. |
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| DOI: | doi:10.1039/c2ob26906f |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1039/c2ob26906f |
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| | DOI: https://doi.org/10.1039/c2ob26906f |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Alkenes |
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| | Animals |
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| | Anti-Bacterial Agents |
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| | Bacillus subtilis |
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| | Cell Proliferation |
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| | Cells, Cultured |
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| | Corynebacterium |
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| | DNA-Directed RNA Polymerases |
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| | Dose-Response Relationship, Drug |
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| | Enzyme Inhibitors |
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| | Fibroblasts |
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| | Macrolides |
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| | Mice |
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| | Microbial Sensitivity Tests |
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| | Molecular Structure |
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| | Organometallic Compounds |
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| | Polyenes |
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| | Structure-Activity Relationship |
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| K10plus-PPN: | 1574258052 |
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| Verknüpfungen: | → Zeitschrift |
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Modular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes / Altendorfer, Mario [VerfasserIn]; 2013 (Online-Ressource)
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