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Verfasst von:Schlecker, Eva [VerfasserIn]   i
 Umansky, Viktor [VerfasserIn]   i
Titel:Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth
Verf.angabe:Eva Schlecker, Ana Stojanovic, Christian Eisen, Christian Quack, Christine S. Falk, Viktor Umansky, and Adelheid Cerwenka
Jahr:2012
Umfang:10 S.
Fussnoten:Gesehen am 09.05.2018
Titel Quelle:Enthalten in: The journal of immunology
Ort Quelle:Rockville, Md. : American Association of Immunologists, 1916
Jahr Quelle:2012
Band/Heft Quelle:189(2012), 12, Seite 5602-5611
ISSN Quelle:1550-6606
Abstract:Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of myeloid cells in cancer patients and tumor-bearing mice that potently inhibits T cell responses. During tumor progression, MDSCs accumulate in several organs, including the tumor tissue. So far, tumor-infiltrating MDSC subpopulations remain poorly explored. In this study, we performed global gene expression profiling of mouse tumor-infiltrating granulocytic and monocytic (MO-MDSC) subsets compared with MDSCs from peripheral blood. RMA-S lymphoma-infiltrating MO-MDSCs not only produced high levels of NO and arginase-1, but also greatly increased levels of chemokines comprising the CCR5 ligands CCL3, CCL4, and CCL5. MO-MDSCs isolated from B16 melanoma and from skin tumor-bearing ret transgenic mice also expressed high levels of CCL3, CCL4, and CCL5. Expression of CCR5 was preferentially detected on regulatory T cells (Tregs). Accordingly, tumor-infiltrating MO-MDSCs directly attracted high numbers of Tregs via CCR5 in vitro. Intratumoral injection of CCL4 or CCL5 increased tumor-infiltrating Tregs, and deficiency of CCR5 led to their profound decrease. Moreover, in CCR5-deficient mice, RMA-S and B16 tumor growth was delayed emphasizing the importance of CCR5 in the control of antitumor immune responses. Overall, our data demonstrate that chemokines secreted by tumor-infiltrating MO-MDSCs recruit high numbers of Tregs revealing a novel suppressive role of MDSCs with potential clinical implications for the development of cancer immunotherapies.
DOI:doi:10.4049/jimmunol.1201018
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: http://dx.doi.org/10.4049/jimmunol.1201018
 kostenfrei: Volltext: http://www.jimmunol.org/content/189/12/5602
 DOI: https://doi.org/10.4049/jimmunol.1201018
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1574284169
Verknüpfungen:→ Zeitschrift

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