Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Schlecker, Eva [VerfasserIn]  |
| Umansky, Viktor [VerfasserIn]  |
Titel: | Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth |
Verf.angabe: | Eva Schlecker, Ana Stojanovic, Christian Eisen, Christian Quack, Christine S. Falk, Viktor Umansky, and Adelheid Cerwenka |
Jahr: | 2012 |
Umfang: | 10 S. |
Fussnoten: | Gesehen am 09.05.2018 |
Titel Quelle: | Enthalten in: The journal of immunology |
Ort Quelle: | Rockville, Md. : American Association of Immunologists, 1916 |
Jahr Quelle: | 2012 |
Band/Heft Quelle: | 189(2012), 12, Seite 5602-5611 |
ISSN Quelle: | 1550-6606 |
Abstract: | Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of myeloid cells in cancer patients and tumor-bearing mice that potently inhibits T cell responses. During tumor progression, MDSCs accumulate in several organs, including the tumor tissue. So far, tumor-infiltrating MDSC subpopulations remain poorly explored. In this study, we performed global gene expression profiling of mouse tumor-infiltrating granulocytic and monocytic (MO-MDSC) subsets compared with MDSCs from peripheral blood. RMA-S lymphoma-infiltrating MO-MDSCs not only produced high levels of NO and arginase-1, but also greatly increased levels of chemokines comprising the CCR5 ligands CCL3, CCL4, and CCL5. MO-MDSCs isolated from B16 melanoma and from skin tumor-bearing ret transgenic mice also expressed high levels of CCL3, CCL4, and CCL5. Expression of CCR5 was preferentially detected on regulatory T cells (Tregs). Accordingly, tumor-infiltrating MO-MDSCs directly attracted high numbers of Tregs via CCR5 in vitro. Intratumoral injection of CCL4 or CCL5 increased tumor-infiltrating Tregs, and deficiency of CCR5 led to their profound decrease. Moreover, in CCR5-deficient mice, RMA-S and B16 tumor growth was delayed emphasizing the importance of CCR5 in the control of antitumor immune responses. Overall, our data demonstrate that chemokines secreted by tumor-infiltrating MO-MDSCs recruit high numbers of Tregs revealing a novel suppressive role of MDSCs with potential clinical implications for the development of cancer immunotherapies. |
DOI: | doi:10.4049/jimmunol.1201018 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: http://dx.doi.org/10.4049/jimmunol.1201018 |
| kostenfrei: Volltext: http://www.jimmunol.org/content/189/12/5602 |
| DOI: https://doi.org/10.4049/jimmunol.1201018 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1574284169 |
Verknüpfungen: | → Zeitschrift |
Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth / Schlecker, Eva [VerfasserIn]; 2012 (Online-Ressource)
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