| Online-Ressource |
Verfasst von: | Höper, Marius [VerfasserIn]  |
| Pan, Zixuan [VerfasserIn]  |
| Eichstaedt, Christina [VerfasserIn]  |
| Benjamin, Nicola [VerfasserIn]  |
| Grünig, Ekkehard [VerfasserIn]  |
Titel: | Mortality in pulmonary arterial hypertension |
Titelzusatz: | prediction by the 2015 European pulmonary hypertension guidelines risk stratification model |
Verf.angabe: | Marius M. Hoeper, Tilmann Kramer, Zixuan Pan, Christina A. Eichstaedt, Jens Spiesshoefer, Nicola Benjamin, Karen M. Olsson, Katrin Meyer, Carmine Dario Vizza, Anton Vonk-Noordegraaf, Oliver Distler, Christian Opitz, J. Simon R. Gibbs, Marion Delcroix, H. Ardeschir Ghofrani, Doerte Huscher, David Pittrow, Stephan Rosenkranz, Ekkehard Grünig |
E-Jahr: | 2017 |
Jahr: | August 3, 2017 |
Umfang: | 10 S. |
Fussnoten: | Gesehen am 09.05.2018 |
Titel Quelle: | Enthalten in: European respiratory journal |
Ort Quelle: | Lausanne : ERS, 1988 |
Jahr Quelle: | 2017 |
Band/Heft Quelle: | 50(2017,2) Artikel-Nummer 1700740, 10 Seiten |
ISSN Quelle: | 1399-3003 |
Abstract: | The 2015 European pulmonary hypertension (PH) guidelines propose a risk stratification strategy for patients with pulmonary arterial hypertension (PAH). Low-, intermediate- and high-risk strata are defined by estimated 1-year mortality risks of <5%, 5-10% and >10%, respectively. This risk assessment strategy awaits validation. We analysed data from patients with newly diagnosed PAH enrolled into COMPERA (Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension), a European-based PH registry. An abbreviated version of the risk assessment strategy proposed by the European PH guidelines was applied, using the following variables: World Health Organization functional class, 6-min walking distance, brain natriuretic peptide or its N-terminal fragment, right atrial pressure, cardiac index and mixed venous oxygen saturation. Data from 1588 patients were analysed. Mortality rates were significantly different between the three risk strata (p<0.001 for all comparisons). In the entire patient population, the observed mortality rates 1 year after diagnosis were 2.8% in the low-risk cohort (n=196), 9.9% in the intermediate-risk cohort (n=1116) and 21.2% in the high-risk cohort (n=276). In addition, the risk assessment strategy proved valid at follow-up and in major PAH subgroups. An abbreviated version of the risk assessment strategy proposed by the current European PH guidelines provides accurate mortality estimates in patients with PAH. Tweetable abstract @ERSpublications click to tweetThe risk stratification strategy proposed by the current European PH guidelines allows accurate survival prediction http://ow.ly/KsWk30c46nK |
DOI: | doi:10.1183/13993003.00740-2017 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: http://dx.doi.org/10.1183/13993003.00740-2017 |
| Volltext: http://erj.ersjournals.com/content/50/2/1700740 |
| DOI: https://doi.org/10.1183/13993003.00740-2017 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1574285394 |
Verknüpfungen: | → Zeitschrift |
Mortality in pulmonary arterial hypertension / Höper, Marius [VerfasserIn]; August 3, 2017 (Online-Ressource)