| |  Online-Ressource |
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| Verfasst von: | Hörner-Rieber, Juliane [VerfasserIn]  |
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| | Bernhardt, Denise [VerfasserIn] |
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| | Dern, Julian [VerfasserIn] |
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| | König, Laila [VerfasserIn] |
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| | Adeberg, Sebastian [VerfasserIn] |
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| | Paul, Angela [VerfasserIn] |
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| | Heußel, Claus Peter [VerfasserIn] |
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| | Kappes, Jutta [VerfasserIn] |
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| | Hoffmann, Hans [VerfasserIn] |
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| | Herth, Felix [VerfasserIn] |
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| | Debus, Jürgen [VerfasserIn] |
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| | Warth, Arne [VerfasserIn] |
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| | Rieken, Stefan [VerfasserIn] |
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| Titel: | Histology of non-small cell lung cancer predicts the response to stereotactic body radiotherapy |
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| Verf.angabe: | Juliane Hörner-Rieber, Denise Bernhardt, Julian Dern, Laila König, Sebastian Adeberg, Angela Paul, Claus Peter Heussel, Jutta Kappes, Hans Hoffmann, Felix J. P. Herth, Jürgen Debus, Arne Warth, Stefan Rieken |
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| E-Jahr: | 2017 |
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| Jahr: | 14 September 2017 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 09.05.2018 |
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| Titel Quelle: | Enthalten in: Radiotherapy and oncology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1983 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 125(2017), 2, Seite 317-324 |
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| ISSN Quelle: | 1879-0887 |
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| Abstract: | Background and purpose: to investigate the prognostic impact of different histological subtypes of non-small cell lung cancer (NSCLC) on outcome following stereotactic body radiotherapy (SBRT) for NSCLC patients. Materials and methods: we analyzed 126 consecutive patients with early-stage adenocarcinoma or squamous cell carcinoma treated with SBRT from 2004 to 2016. Adenocarcinoma patients were further sub-classified as high-risk or low-risk tumors. Results: with a median follow-up time of 22months, 2-year overall survival (OS), local (LC), and distant control (DC) were 68%, 90% and 79%, respectively. For LC, histologic subtype was identified as major independent prognostic factor (p=0.033): while LC was 81% for squamous cell carcinoma patients, LC was significantly improved for high-risk and even more non-high-risk adenocarcinoma patients with 96% and 100%, respectively (p=0.026). The negative prognostic impact of the histologic subtype “squamous cell carcinoma” was not evident when patients received SBRT with higher total doses in EQD2 (2Gy equivalent dose): if patients were treated with a total dose in EQD2≥150Gy, no significant difference in LC for histologic subtypes was detected anymore (p=0.355). Conclusion: in the current study, histologic subtypes of NSCLC predicted local control probabilities following SBRT. Prospective, multi-center studies are needed to evaluate the prognostic impact of histology and consecutively the need for SBRT dose adaptation. |
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| DOI: | doi:10.1016/j.radonc.2017.08.029 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1016/j.radonc.2017.08.029 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0167814017325537 |
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| | DOI: https://doi.org/10.1016/j.radonc.2017.08.029 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Adenocarcinoma |
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| | Histologic subtype |
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| | Non-small cell lung cancer |
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| | Squamous cell carcinoma |
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| | Stereotactic body radiotherapy (SBRT) |
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| K10plus-PPN: | 1574298488 |
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| Verknüpfungen: | → Zeitschrift |
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Histology of non-small cell lung cancer predicts the response to stereotactic body radiotherapy / Hörner-Rieber, Juliane [VerfasserIn]; 14 September 2017 (Online-Ressource)
