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Status: Bibliographieeintrag

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Verfasst von:Hörner-Rieber, Juliane [VerfasserIn]   i
 Bernhardt, Denise [VerfasserIn]   i
 Dern, Julian [VerfasserIn]   i
 König, Laila [VerfasserIn]   i
 Adeberg, Sebastian [VerfasserIn]   i
 Paul, Angela [VerfasserIn]   i
 Heußel, Claus Peter [VerfasserIn]   i
 Kappes, Jutta [VerfasserIn]   i
 Hoffmann, Hans [VerfasserIn]   i
 Herth, Felix [VerfasserIn]   i
 Debus, Jürgen [VerfasserIn]   i
 Warth, Arne [VerfasserIn]   i
 Rieken, Stefan [VerfasserIn]   i
Titel:Histology of non-small cell lung cancer predicts the response to stereotactic body radiotherapy
Verf.angabe:Juliane Hörner-Rieber, Denise Bernhardt, Julian Dern, Laila König, Sebastian Adeberg, Angela Paul, Claus Peter Heussel, Jutta Kappes, Hans Hoffmann, Felix J. P. Herth, Jürgen Debus, Arne Warth, Stefan Rieken
E-Jahr:2017
Jahr:14 September 2017
Umfang:8 S.
Fussnoten:Gesehen am 09.05.2018
Titel Quelle:Enthalten in: Radiotherapy and oncology
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1983
Jahr Quelle:2017
Band/Heft Quelle:125(2017), 2, Seite 317-324
ISSN Quelle:1879-0887
Abstract:Background and purpose: to investigate the prognostic impact of different histological subtypes of non-small cell lung cancer (NSCLC) on outcome following stereotactic body radiotherapy (SBRT) for NSCLC patients. Materials and methods: we analyzed 126 consecutive patients with early-stage adenocarcinoma or squamous cell carcinoma treated with SBRT from 2004 to 2016. Adenocarcinoma patients were further sub-classified as high-risk or low-risk tumors. Results: with a median follow-up time of 22months, 2-year overall survival (OS), local (LC), and distant control (DC) were 68%, 90% and 79%, respectively. For LC, histologic subtype was identified as major independent prognostic factor (p=0.033): while LC was 81% for squamous cell carcinoma patients, LC was significantly improved for high-risk and even more non-high-risk adenocarcinoma patients with 96% and 100%, respectively (p=0.026). The negative prognostic impact of the histologic subtype “squamous cell carcinoma” was not evident when patients received SBRT with higher total doses in EQD2 (2Gy equivalent dose): if patients were treated with a total dose in EQD2≥150Gy, no significant difference in LC for histologic subtypes was detected anymore (p=0.355). Conclusion: in the current study, histologic subtypes of NSCLC predicted local control probabilities following SBRT. Prospective, multi-center studies are needed to evaluate the prognostic impact of histology and consecutively the need for SBRT dose adaptation.
DOI:doi:10.1016/j.radonc.2017.08.029
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.radonc.2017.08.029
 Volltext: http://www.sciencedirect.com/science/article/pii/S0167814017325537
 DOI: https://doi.org/10.1016/j.radonc.2017.08.029
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adenocarcinoma
 Histologic subtype
 Non-small cell lung cancer
 Squamous cell carcinoma
 Stereotactic body radiotherapy (SBRT)
K10plus-PPN:1574298488
Verknüpfungen:→ Zeitschrift

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