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Verfasst von:Ruggeri, Barbara [VerfasserIn]   i
 Flor, Herta [VerfasserIn]   i
 Banaschewski, Tobias [VerfasserIn]   i
 Nees, Frauke [VerfasserIn]   i
 Poustka, Luise [VerfasserIn]   i
 Sommer, Wolfgang H. [VerfasserIn]   i
Titel:Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents
Verf.angabe:Barbara Ruggeri, Christine Macare, Serena Stopponi, Tianye Jia, Fabiana M. Carvalho, Gabriel Robert, Tobias Banaschewski, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Anna Cattrell, Patricia J. Conrod, Sylvane Desrivières, Herta Flor, Vincent Frouin, Jürgen Gallinat, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean Luc Martinot, Marie‐Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos‐Orfanos, Tomáš Paus, Luise Poustka, Michael N. Smolka, Nora C. Vetter, Henrik Walter, Robert Whelan, Wolfgang H. Sommer, Georgy Bakalkin, Roberto Ciccocioppo, Gunter Schumann and the IMAGEN consortium
E-Jahr:2017
Jahr:2 December 2017
Umfang:9 S.
Fussnoten:Gesehen am 09.05.2018
Titel Quelle:Enthalten in: The journal of child psychology and psychiatry
Ort Quelle:Oxford : Wiley-Blackwell, 1960
Jahr Quelle:2017
Band/Heft Quelle:2 December 2017, ahead of print, 9 Seiten
ISSN Quelle:1469-7610
Abstract:Abstract Background: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders. Methods: Here, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity. Results: We found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens. Conclusions: Our findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse.
DOI:doi:10.1111/jcpp.12843
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1111/jcpp.12843
 DOI: https://doi.org/10.1111/jcpp.12843
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1574316354
Verknüpfungen:→ Zeitschrift

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