Plasmodium sporozoite biology

• Verfasst von: Frischknecht, Friedrich [VerfasserIn]
• Verfasst von: Matuschewski, Kai [VerfasserIn]
• Titel: Plasmodium sporozoite biology
• Verf.angabe: Friedrich Frischknecht, Kai Matuschewski
• Fussnoten: Gesehen am 11.05.2018
• Titel Quelle: Enthalten in: Cold Spring Harbor perspectives in medicine
• Jahr Quelle: 2017
• Band/Heft Quelle: 7(2017,5) Artikel-Nummer a025478
• ISSN Quelle: 2157-1422
• DOI: doi:10.1101/cshperspect.a025478
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1574988093

Abstract

Plasmodium sporozoite transmission is a critical population bottleneck in parasite life-cycle progression and, hence, a target for prophylactic drugs and vaccines. The recent progress of a candidate antisporozoite subunit vaccine formulation to licensure highlights the importance of sporozoite transmission intervention in the malaria control portfolio. Sporozoites colonize mosquito salivary glands, migrate through the skin, penetrate blood vessels, breach the liver sinusoid, and invade hepatocytes. Understanding the molecular and cellular mechanisms that mediate the remarkable sporozoite journey in the invertebrate vector and the vertebrate host can inform evidence-based next-generation drug development programs and immune intervention strategies.