Aberrant peak lactate response in MS

• Verfasst von: Schlüter, Kathrin [VerfasserIn]
• Titel: Aberrant peak lactate response in MS
• Verf.angabe: Kathrin Schlüter, Josephina Maier, Stefan Patra, Stefan M. Gold, Christoph Heesen, Karl-Heinz Schulz
• Jahr: 2017
• Umfang: 12 S.
• Fussnoten: Gesehen am 14.05.2018
• Titel Quelle: Enthalten in: Neurorehabilitation
• Ort Quelle: Amsterdam : IOS Press, 1995
• Jahr Quelle: 2017
• Band/Heft Quelle: 41(2017), 4, Seite 811-822
• ISSN Quelle: 1878-6448
• DOI: doi:10.3233/NRE-172182
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1575004208

Abstract

BACKGROUND: The peak blood lactate response to an exhaustive exercise test in a number of chronic conditions has been shown to differ from that seen in healthy, untrained individuals. However, this has not been investigated for patients with multiple sclerosis (MS). OBJECTIVE: The main objective was to determine and compare the peak blood lactate response to exercise and the maximal workload between two groups of MS patients with different illness severity. METHODS: Twenty-five patients with a relapsing-remitting disease course (Group RR) and 41 patients with a secondary- or primary chronic progressive disease course (group CP) performed an exhaustive incremental bicycle ergometry. Peak blood lactate, maximal workload, peak oxygen consumption and maximal heart rate were measured. RESULTS: The peak blood lactate levels and maximal workload differed significantly between the groups (group CP<group RR; p<0.001). Furthermore spiroergometric peak performance markers in both groups were significantly lower than predicted for healthy age and sex matched untrained groups. CONCLUSION: A reduced peak blood lactate response to exercise is a novel finding for MS patients. This calls into doubt if the lactate performance tests and lactate thresholds used for healthy individuals can be transferred to MS patients.