Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Jędrzejczak, Wiesław [VerfasserIn]   i
 Dreger, Peter [VerfasserIn]   i
Titel:Hematopoietic stem cell transplantation in T-prolymphocytic leukemia
Titelzusatz:a retrospective study from the European Group for Blood and Marrow Transplantation and the Royal Marsden Consortium
Verf.angabe:W. Wiktor-Jedrzejczak, C. Dearden, L. de Wreede, A. van Biezen, L. Brinch, V. Leblond, M. Brune, L. Volin, M. Kazmi, A. Nagler, J. Schetelig, T. de Witte and P. Dreger
Jahr:2012
Jahr des Originals:2011
Umfang:5 S.
Fussnoten:Published online: 25 November 2011 ; Gesehen am 14.05.2018
Titel Quelle:Enthalten in: Leukemia
Ort Quelle:London : Springer Nature, 1997
Jahr Quelle:2012
Band/Heft Quelle:26(2012), 5, Seite 972-976
ISSN Quelle:1476-5551
Abstract:T-prolymphocytic leukemia (T-PLL) has a very poor prognosis with conventional immunochemotherapy. Incidental reports suggest that allogeneic hematopoietic stem cell transplantation (allo-HSCT) might have a role in this disease. Therefore, the purpose of the present study was to analyze the outcome of transplants for T-PLL registered with the European Group for Blood and Marrow Transplantation database and the Royal Marsden Consortium. Eligible were 41 patients with a median age of 51 (24-71) years; median time from diagnosis to treatment was 12 months, and in complete remission (CR) (11), partial remission (PR) (12), stable or progressive disease (13) and unknown in 5 patients. A total of 13 patients (31%) received reduced-intensity conditioning. Donors were HLA-identical siblings in 21 patients, matched unrelated donors in 20 patients. With a median follow-up of surviving patients of 36 months, 3-year relapse-free survival (RFS) and OS was 19% (95% CI, 6-31%) and 21% (95% CI, 7-34%), respectively. Multivariate analysis identified TBI and a short interval between diagnosis and HSCT as factors associated with favorable RFS. Three-year non relapse mortality and relapse incidence were each 41% with the majority of relapses occurring within the first year. These data indicate that allo-HSCT may provide effective disease control in selected patients with T-PLL.
DOI:doi:10.1038/leu.2011.304
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1038/leu.2011.304
 Volltext: https://www.nature.com/articles/leu2011304
 DOI: https://doi.org/10.1038/leu.2011.304
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1575021919
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68251879   QR-Code
zum Seitenanfang