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Verfasst von:Rupp, Christian [VerfasserIn]   i
 Mummelthei, Anne [VerfasserIn]   i
 Sauer, Peter [VerfasserIn]   i
 Weiss, Karl Heinz [VerfasserIn]   i
 Schirmacher, Peter [VerfasserIn]   i
 Stiehl, Adolf [VerfasserIn]   i
 Stremmel, Wolfgang [VerfasserIn]   i
 Gotthardt, Daniel [VerfasserIn]   i
Titel:Non-IBD immunological diseases are a risk factor for reduced survival in PSC
Verf.angabe:Christian Rupp, Anne Mummelthei, Peter Sauer, Karl H. Weiss, Peter Schirmacher, Adolf Stiehl, Wolfgang Stremmel and Daniel N. Gotthardt
Jahr:2012
Umfang:8 S.
Teil:volume:33
 year:2013
 number:1
 pages:86-93
 extent:8
Fussnoten:Gesehen am 15.05.2018
Titel Quelle:Enthalten in: Liver international
Ort Quelle:Oxford : Wiley-Blackwell, 2003
Jahr Quelle:2013
Band/Heft Quelle:33(2013), 1, Seite 86-93
ISSN Quelle:1478-3231
Abstract:Abstract: Background: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease. It is known to be associated with immunological diseases (IDs), such as inflammatory bowel disease (IBD) and autoimmune hepatitis (AIH). Aim: We evaluated the presence of IDs be sides IBD and AIH in a cohort of PSC patients, and its association with clinical outcome. Methods: This is a prospective cohort study of 195 PSC patients that were evaluated over the period 1987 – 2010 in ou r tertiary care centre. The presence of ID was determined using a retrospective chart review. IDs were subclassified into autoimmune disease (AID) and immune-mediated inflammatory disease (IMID), according to current guidelines. Results: Twenty-seven of 195 (13.8%) PSC patients had at least one additional ID other than IBD (70%) or AIH (5%). The most frequent AIDs were autoimmune thyroiditis (2.6%) and diabetes mellitus type 1 (2.1%). The most frequent IMIDs were psoriasis (3.6%) and sarcoidosis (2.1%). After more than 20 years of follow-up, concomitant IDs repre sent an independent risk factor for reduced transplantation-free survival in patients with PSC (mean: 8.9 years vs. 16.3 years, P = 0.012). Further subgroup analysis revealed a significantly reduced survival especial ly in patients with concomitant IMID (P = 0.017). Conclusion: Patients with concomitant IDs, especially IMID, are a clinically important subgroup of PSC patients. This significant phenotype warrants further genetic and immunological studies.
DOI:doi:10.1111/liv.12028
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1111/liv.12028
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/liv.12028
 DOI: https://doi.org/10.1111/liv.12028
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:autoimmune liver disease
 biliary tract
 cholestatic liver disease
 Primary sclerosing cholangitis
 retinoid metabolism
K10plus-PPN:1575150492
Verknüpfungen:→ Zeitschrift

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