| |  Online-Ressource |
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| Verfasst von: | Aly, Mostafa Gaafa [VerfasserIn]  |
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| | Zhu, Li [VerfasserIn] |
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| | Opelz, Gerhard [VerfasserIn] |
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| | Morath, Christian [VerfasserIn] |
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| | Kuon, Ruben-Jeremias [VerfasserIn] |
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| | Daniel, Volker [VerfasserIn] |
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| Titel: | Low utility of serum 25-hydroxyvitamin D3 and 1, 25-dihydroxyvitamin D3 in predicting peripheral Treg and Th17 cell counts in ESRD and renal transplant patients |
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| Verf.angabe: | Mostafa G. Aly, Li Zhu, Rolf Weimer, Gerhard Opelz, Christian Morath, Ruben Kuon, Mohammed Tohamy, Gamal Saadi, Mona Soliman, Walaa Ibrahim, Volker Daniel |
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| E-Jahr: | 2017 |
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| Jahr: | 27 July 2017 |
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| Umfang: | 8 S. |
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| Teil: | volume:43/44 |
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| | year:2017 |
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| | pages:3-10 |
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| | extent:8 |
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| Fussnoten: | Gesehen am 16.05.2018 |
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| Titel Quelle: | Enthalten in: Transplant immunology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 1993 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 43/44(2017), Seite 3-10 |
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| ISSN Quelle: | 1878-5492 |
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| Abstract: | BACKGROUND: Vitamin D has shown an immune-modulatory effect in different studies. Vitamin D stimulates Tregs and inhibits Th17 cells. The immune-modulatory role of vitamin D in chronic kidney disease (CKD) and renal transplant patients is unclear. We measured whether different serum levels of vitamin D were associated with an increased or decreased presence of lymphocyte subsets including Treg and Th17 cells in end-stage renal disease (ESRD) and renal transplant recipients. METHODS: Eighty-seven renal transplant recipients and 53 end-stage renal disease (ESRD) patients were enrolled in this study. The absolute counts of CD4+ and CD8+ T, CD16+ CD56+ NK, CD19+ B, CD4+ CD25+ CD127- Foxp3+ (Tregs), Helios+ Tregs, CD38+ Tregs, and CD4+ CD17+ (Th17) cells were analyzed in peripheral blood in both patient groups. In addition, serum 25 (OH) D3, 1, 25 (OH)2 D3, IL-6, IL-17, IL-23, and TGF-β1 were measured. The association between lymphocyte subset counts and 1, 25 (OH)2 D3 or 25 (OH) D3 was studied, as was the association between serum IL-6, IL-17, IL-23, or TGF-β1 and 1,25 (OH)2 D3 or 25 (OH) D3. RESULTS: Serum 25 (OH) D3 and 1,25 (OH)2 D3 levels were not independently associated with peripheral CD4+ T, CD19+ B, CD16+ CD56+ NK, Treg, or Th17 cell counts. In contrast to serum 25 (OH) D3, serum1, 25 (OH)2 D3 was positively associated with CD8+ T cells counts in renal transplant recipients. CONCLUSION: Our findings indicate low utility of serum 25 (OH) D3 and 1, 25 (OH)2 D3 levels in predicting a change in lymphocyte subset counts in ESRD and renal transplant patients. |
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| DOI: | doi:10.1016/j.trim.2017.07.003 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1016/j.trim.2017.07.003 |
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| | DOI: https://doi.org/10.1016/j.trim.2017.07.003 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | 1, 25 (OH)(2) D(3) |
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| | 25 (OH) D(3) |
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| | Adult |
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| | Calcifediol |
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| | Calcitriol |
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| | CD4 Lymphocyte Count |
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| | Cytokines |
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| | Female |
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| | Humans |
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| | Kidney Failure, Chronic |
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| | Kidney Transplantation |
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| | Male |
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| | Middle Aged |
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| | Renal transplantation |
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| | T-Lymphocytes, Regulatory |
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| | Th17 |
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| | Th17 Cells |
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| | Treg |
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| K10plus-PPN: | 1575173972 |
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| Verknüpfungen: | → Zeitschrift |
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Low utility of serum 25-hydroxyvitamin D3 and 1, 25-dihydroxyvitamin D3 in predicting peripheral Treg and Th17 cell counts in ESRD and renal transplant patients / Aly, Mostafa Gaafa [VerfasserIn]; 27 July 2017 (Online-Ressource)
