Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:El-Daly, Sherien M. [VerfasserIn]   i
 Abba, Mohammed L. [VerfasserIn]   i
 Gamal-Eldeen, Amira M. [VerfasserIn]   i
Titel:The role of microRNAs in photodynamic therapy of cancer
Verf.angabe:Sherien M. El-Daly, Mohammed L. Abba, Amira M. Gamal-Eldeen
E-Jahr:2017
Jahr:15 December 2017
Umfang:6 S.
Fussnoten:Gesehen am 16.05.2018
Titel Quelle:Enthalten in: European journal of medicinal chemistry
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1987
Jahr Quelle:2017
Band/Heft Quelle:142(2017), Seite 550-555
ISSN Quelle:1768-3254
Abstract:Photodynamic therapy (PDT) is a non-invasive treatment modality used in the management of both benign and malignant conditions. It involves the administration of a photosensitizing agent followed by local light irradiation, which activates the photosensitizer, resulting in tissue damage. An in-depth understanding of the molecular mechanisms and mediators of PDT is important, not only for appreciating how this treatment modality is effective, but also as an avenue for understanding potential shortfalls and untoward effects that can be managed or improved. MicroRNAs are a group of endogenous small non-coding regulatory molecules that play important roles in regulating several physiological processes and have been implicated in several pathologies including cancer. They have been found to regulate key cellular pathways and their aberrant expression highlights not only disease onset or progression, but is associated with therapy resistance and disease outcome. In the present review, we evaluate the role of microRNAs in PDT and dissect their function as effectors of PDT including the molecules they regulate. We also look at how miRNA signatures can be used as predictors of therapy response to PDT and what implications this may have in the treatment of patients with PDT.
DOI:doi:10.1016/j.ejmech.2017.10.011
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.ejmech.2017.10.011
 Volltext: http://www.sciencedirect.com/science/article/pii/S0223523417308036
 DOI: https://doi.org/10.1016/j.ejmech.2017.10.011
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Apoptosis
 Microarray
 MicroRNAs
 Photodynamic therapy
 Photosensitizers
K10plus-PPN:1575185504
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68252576   QR-Code
zum Seitenanfang