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Verfasst von:Akdeniz, Ceren [VerfasserIn]   i
 Wüst, Stefan [VerfasserIn]   i
 Kirsch, Peter [VerfasserIn]   i
 Meyer-Lindenberg, Andreas [VerfasserIn]   i
Titel:Sex-dependent association of perigenual anterior cingulate cortex volume and migration background, an environmental risk factor for schizophrenia
Verf.angabe:Ceren Akdeniz, Axel Schäfer, Fabian Streit, Leila Haller, Stefan Wüst, Peter Kirsch, Heike Tost, and Andreas Meyer-Lindenberg
E-Jahr:2017
Jahr:1 July 2017
Umfang:10 S.
Fussnoten:Gesehen am 17.05.2018
Titel Quelle:Enthalten in: Schizophrenia bulletin
Ort Quelle:Oxford : Oxford Univ. Press, 1969
Jahr Quelle:2017
Band/Heft Quelle:43(2017), 4, Seite 925-934
ISSN Quelle:1745-1701
Abstract:Migration status is one of the best-established risk factors for schizophrenia. An increase in risk is observed in both first- and second-generation immigrants, with a varying magnitude depending on the ethnic background of the individuals. The underlying mechanisms for the increased risk are only recently coming into focus. A causal role for social stress has been widely proposed, and recent work indicated altered neural stress processing in the perigenual anterior cingulate cortex (pACC) in migrants. Since previous work shows that social stress may lead to enduring changes in the gray matter volume of vulnerable brain regions, we investigated the impact of migration background on brain structure. We studied healthy young adults (N = 124), native Germans and second-generation migrants, using whole-brain structural magnetic resonance imaging. Groups were matched for a broad range of sociodemographic characteristics including age, gender, urban exposure, and education. We found a significant group by sex interaction effect in pACC gray matter volume, which was reduced in males with migration background only. This mirrors previous findings in urban upbringing, another risk factor for schizophrenia. Our results provide convergent evidence for an impact of environmental risk factors linked to schizophrenia on gray matter volume and extend prior data by highlighting the possibility that the pACC structure may be particularly sensitive to the convergent risk factors linked to schizophrenia.
DOI:doi:10.1093/schbul/sbw138
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1093/schbul/sbw138
 Volltext: https://academic-oup-com.ezproxy.medma.uni-heidelberg.de/schizophreniabulletin/article/43/4/925/2503804
 DOI: https://doi.org/10.1093/schbul/sbw138
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1575280051
Verknüpfungen:→ Zeitschrift

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