| Online-Ressource |
Verfasst von: | Bender, Stephan [VerfasserIn]  |
| Resch, Franz [VerfasserIn]  |
| Rietschel, Marcella [VerfasserIn]  |
| Brandeis, Daniel [VerfasserIn]  |
| Banaschewski, Tobias [VerfasserIn]  |
| Laucht, Manfred [VerfasserIn]  |
Titel: | Time-resolved influences of functional DAT1 and COMT variants on visual perception and post-processing |
Verf.angabe: | Stephan Bender, Thomas Rellum, Christine Freitag, Franz Resch, Marcella Rietschel, Jens Treutlein, Christine Jennen-Steinmetz, Daniel Brandeis, Tobias Banaschewski, Manfred Laucht |
E-Jahr: | 2012 |
Jahr: | July 23, 2012 |
Umfang: | 12 S. |
Fussnoten: | Gesehen am 17.05.2018 |
Titel Quelle: | Enthalten in: PLOS ONE |
Ort Quelle: | San Francisco, California, US : PLOS, 2006 |
Jahr Quelle: | 2012 |
Band/Heft Quelle: | 7(2012,7) Artikel-Nummer e41552, 12 Seiten |
ISSN Quelle: | 1932-6203 |
Abstract: | Background Dopamine plays an important role in orienting and the regulation of selective attention to relevant stimulus characteristics. Thus, we examined the influences of functional variants related to dopamine inactivation in the dopamine transporter (DAT1) and catechol-O-methyltransferase genes (COMT) on the time-course of visual processing in a contingent negative variation (CNV) task. Methods 64-channel EEG recordings were obtained from 195 healthy adolescents of a community-based sample during a continuous performance task (A-X version). Early and late CNV as well as preceding visual evoked potential components were assessed. Results Significant additive main effects of DAT1 and COMT on the occipito-temporal early CNV were observed. In addition, there was a trend towards an interaction between the two polymorphisms. Source analysis showed early CNV generators in the ventral visual stream and in frontal regions. There was a strong negative correlation between occipito-temporal visual post-processing and the frontal early CNV component. The early CNV time interval 500-1000 ms after the visual cue was specifically affected while the preceding visual perception stages were not influenced. Conclusions Late visual potentials allow the genomic imaging of dopamine inactivation effects on visual post-processing. The same specific time-interval has been found to be affected by DAT1 and COMT during motor post-processing but not motor preparation. We propose the hypothesis that similar dopaminergic mechanisms modulate working memory encoding in both the visual and motor and perhaps other systems. |
DOI: | doi:10.1371/journal.pone.0041552 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: http://dx.doi.org/10.1371/journal.pone.0041552 |
| kostenfrei: Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041552 |
| DOI: https://doi.org/10.1371/journal.pone.0041552 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Working memory |
| Dopamine |
| Dopaminergics |
| Haplotypes |
| Reaction time |
| Sensory cues |
| Variant genotypes |
| Vision |
K10plus-PPN: | 1575282577 |
Verknüpfungen: | → Zeitschrift |
Time-resolved influences of functional DAT1 and COMT variants on visual perception and post-processing / Bender, Stephan [VerfasserIn]; July 23, 2012 (Online-Ressource)