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Verfasst von:Betge, Johannes [VerfasserIn]   i
 Ebert, Matthias [VerfasserIn]   i
Titel:Lymph node retrieval in colorectal cancer
Titelzusatz:determining factors and prognostic significance
Verf.angabe:Johannes Betge, Lars Harbaum, Marion J. Pollheimer, Richard A. Lindtner, Peter Kornprat, Matthias P. Ebert, Cord Langner
E-Jahr:2017
Jahr:16 February 2017
Umfang:8 S.
Fussnoten:Gesehen am 17.05.2018
Titel Quelle:Enthalten in: International journal of colorectal disease
Ort Quelle:Berlin : Springer, 1986
Jahr Quelle:2017
Band/Heft Quelle:32(2017), 7, Seite 991-998
ISSN Quelle:1432-1262
Abstract:Purpose: The study aimed to analyze clinicopathological factors that determine the extent of lymph node retrieval and to evaluate its prognostic impact in patients with colorectal cancer (CRC). Methods: The number of retrieved lymph nodes was analyzed in 381 CRC specimens. Lymph node count was related to different clinicopathological variables by binary logistic regression. Progression-free survival (PFS) and cancer-specific survival (CSS) were determined using the Kaplan-Meier method and Cox regression models. Results: The median number of retrieved lymph nodes was 20 (mean 21 ± 10, range 1-65) in right-sided, 13 (16 ± 10, 1-66) in left-sided, and 15 (18 ± 11, 3-64) in rectal tumors. The number of retrieved lymph nodes was independently associated with T-classification (p < 0.001), N-classification (p = 0.014), and tumor size (p = 0.005) as well as right-sided tumor location (p = 0.012). There was no association with age, sex, tumor grade, mismatch-repair status, and lymph or blood vessel invasion. The longer the surgical specimen, the higher were the numbers of retrieved and positive lymph nodes (p < 0.001, respectively). In patients with locally advanced (T3/T4) tumors (n = 283), analysis of more than 12 lymph nodes was independently associated with PFS (HR = 0.63, p = 0.025) and CSS (HR = 0.54, p = 0.004). In the subset of T3/T4 N0 patients (n = 130), analysis of more than 12 lymph nodes similarly proved to be an independent predictor of outcome (PFS, HR = 0.48, p = 0.046; OS, HR = 0.41, p = 0.026). Conclusion: The number of retrieved lymph nodes is associated with higher tumor stage, tumor size, and right-sided location. Low lymph node count indicates adverse outcome in patients with locally advanced (T3/T4) disease.
DOI:doi:10.1007/s00384-017-2778-8
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1007/s00384-017-2778-8
 Volltext: https://link-springer-com.ezproxy.medma.uni-heidelberg.de/article/10.1007/s00384-017-2778-8
 DOI: https://doi.org/10.1007/s00384-017-2778-8
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1575282852
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