Recent advances in 18F radiochemistry

• Verfasst von: Bernard-Gauthier, Vadim [VerfasserIn]
• Verfasst von: Wängler, Björn [VerfasserIn]
• Titel: Recent advances in 18F radiochemistry
• Titelzusatz: a focus on B-18F, Si-18F, Al-18F, and C-18F radiofluorination via spirocyclic iodonium ylides
• Verf.angabe: Vadim Bernard-Gauthier, Mathieu L. Lepage, Bjoern Waengler, Justin J. Bailey, Steven H. Liang, David M. Perrin, Neil Vasdev and Ralf Schirrmacher
• Jahr: 2018
• Jahr des Originals: 2017
• Umfang: 5 S.
• Fussnoten: Im Titel ist die Zahl "18" jeweils hochgestellt ; Gesehen am 18.05.2018 ; Published online Dec. 28, 2017
• Titel Quelle: Enthalten in: Journal of nuclear medicine
• Ort Quelle: New York, NY : Soc., 1964
• Jahr Quelle: 2018
• Band/Heft Quelle: 59(2018), 4, Seite 568-572
• ISSN Quelle: 2159-662X
• ISSN Quelle: 1535-5667
• DOI: doi:10.2967/jnumed.117.197095
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: fluorine-18
• Sach-SW: radiochemistry
• Sach-SW: radiofluorination
• Sach-SW: spirocyclic iodonium
• K10plus-PPN: 1575293714

Abstract

Straightforward radiosynthesis protocols for 18F-labeled radiopharmaceuticals are an indispensable but often overlooked prerequisite to successfully perform molecular imaging studies in vivo by PET. In recent years, thanks to the expansion of the 18F chemical toolbox, structurally diverse and novel clinically relevant radiopharmaceuticals have been synthesized with both high efficiency and ready implementation. This article provides an overview of recent 18F-labeling methodologies, specifically for B-18F, Si-18F, Al-18F, and iodine (III)-mediated radiofluorination via the spirocyclic iodonium ylide technology.