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Verfasst von:Schmidt, Arthur [VerfasserIn]   i
 Beyna, Torsten [VerfasserIn]   i
 Schumacher, Brigitte [VerfasserIn]   i
 Meining, Alexander [VerfasserIn]   i
 Richter-Schrag, Hans-Juergen [VerfasserIn]   i
 Messmann, Helmut [VerfasserIn]   i
 Neuhaus, Horst [VerfasserIn]   i
 Albers, David [VerfasserIn]   i
 Birk, Michael [VerfasserIn]   i
 Thimme, Robert [VerfasserIn]   i
 Probst, Andreas [VerfasserIn]   i
 Faehndrich, Martin [VerfasserIn]   i
 Frieling, Thomas [VerfasserIn]   i
 Goetz, Martin [VerfasserIn]   i
 Riecken, Bettina [VerfasserIn]   i
 Caca, Karel [VerfasserIn]   i
Titel:Colonoscopic full-thickness resection using an over-the-scope device
Titelzusatz:a prospective multicentre study in various indications
Verf.angabe:Arthur Schmidt, Torsten Beyna, Brigitte Schumacher, Alexander Meining, Hans-Juergen Richter-Schrag, Helmut Messmann, Horst Neuhaus, David Albers, Michael Birk, Robert Thimme, Andreas Probst, Martin Faehndrich, Thomas Frieling, Martin Goetz, Bettina Riecken, Karel Caca
Jahr:2018
Umfang:10 S.
Illustrationen:Illustrationen
Fussnoten:Erstmals online veröffentlicht 10 August 2017 ; Gesehen am 11.11.2024
Titel Quelle:Enthalten in: Gut
Ort Quelle:London : BMJ Publishing Group, 1960
Jahr Quelle:2018
Band/Heft Quelle:67(2018), 7 vom: Juli, Seite 1280-1289
ISSN Quelle:1468-3288
Abstract:Objective: Endoscopic full-thickness resection (EFTR) is a novel treatment of colorectal lesions not amenable to conventional endoscopic resection. The aim of this prospective multicentre study was to assess the efficacy and safety of the full-thickness resection device. Design: 181 patients were recruited in 9 centres with the indication of difficult adenomas (non-lifting and/or at difficult locations), early cancers and subepithelial tumours (SET). Primary endpoint was complete en bloc and R0 resection. Results: EFTR was technically successful in 89.5%, R0 resection rate was 76.9%. In 127 patients with difficult adenomas and benign histology, R0 resection rate was 77.7%. In 14 cases, lesions harboured unsuspected cancer, another 15 lesions were primarily known as cancers. Of these 29 cases, R0 resection was achieved in 72.4%; 8 further cases had deep submucosal infiltration >1000 µm. Therefore, curative resection could only be achieved in 13/29 (44.8%). In the subgroup with SET (n=23), R0 resection rate was 87.0%. In general, R0 resection rate was higher with lesions ≤2 cm vs >2 cm (81.2% vs 58.1%, p=0.0038). Adverse event rate was 9.9% with a 2.2% rate of emergency surgery. Three-month follow-up was available from 154 cases and recurrent/residual tumour was evident in 15.3%. Conclusion: EFTR has a reasonable technical efficacy especially in lesions ≤2 cm with acceptable complication rates. Curative resection rate for early cancers was too low to recommend its primary use in this indication. Further comparative studies have to show the clinical value and long-term outcome of EFTR in benign colorectal lesions. Trial registration number: NCT02362126; Results.
DOI:doi:10.1136/gutjnl-2016-313677
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1136/gutjnl-2016-313677
 Volltext: https://gut.bmj.com/content/67/7/1280
 Volltext: http://dx.doi.org/10.1136/gutjnl-2016-313677
 Volltext: http://gut.bmj.com/content/early/2017/08/10/gutjnl-2016-313677
 DOI: https://doi.org/10.1136/gutjnl-2016-313677
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:EFTR
 endoscopic full-thickness resection
 FTRD
 non-lifting adenomas
K10plus-PPN:1575371421
Verknüpfungen:→ Zeitschrift

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