Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Knebel Doeberitz, Magnus von [VerfasserIn]  |
| Reuschenbach, Miriam [VerfasserIn]  |
| Schmidt, Dietmar [VerfasserIn]  |
Titel: | Biomarkers for cervical cancer screening |
Titelzusatz: | the role of p16INK4a to highlight transforming HPV infections |
Verf.angabe: | Magnus von Knebel Doeberitz, Miriam Reuschenbach, Dietmar Schmidt, Christine Bergeron |
Umfang: | 15 S. |
Fussnoten: | Gesehen am 23.05.2018 |
Titel Quelle: | Enthalten in: Expert review of proteomics |
Jahr Quelle: | 2012 |
Band/Heft Quelle: | 9(2012), 2, S. 149-163 |
ISSN Quelle: | 1744-8387 |
Abstract: | Biomarkers indicating the initiation of neoplastic transformation processes in human papillomavirus (HPV)-infected epithelial cells are moving into the focus of cancer prevention research, particularly for anogenital cancer, including cancer of the uterine cervix. Based on the in-depth understanding of the molecular events leading to neoplastic transformation of HPV-infected human cells, the cyclin-dependent kinase inhibitor p16INK4a turned out to be substantially overexpressed in virtually all HPV-transformed cells. This finding opened novel avenues in diagnostic histopathology to substantially improve the diagnostic accuracy of cervical cancer and its precursor lesions. Furthermore, it provides a novel technical platform to substantially improve the accuracy of cytology-based cancer early-detection programs. Here, we review the molecular background and the current evidence for the clinical utility of the p16INK4a biomarker for HPV-related cancers, and cervical cancer prevention in particular. |
DOI: | doi:10.1586/epr.12.13 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Verlag: http://dx.doi.org/10.1586/epr.12.13 |
| Verlag: https://doi.org/10.1586/epr.12.13 |
| DOI: https://doi.org/10.1586/epr.12.13 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1575448475 |
Verknüpfungen: | → Zeitschrift |
Biomarkers for cervical cancer screening / Knebel Doeberitz, Magnus ¬von¬ [VerfasserIn] (Online-Ressource)
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