| |  Online-Ressource |
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| Verfasst von: | Bernhardt, Denise [VerfasserIn]  |
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| | Adeberg, Sebastian [VerfasserIn] |
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| | Bozorgmehr, Farastuk [VerfasserIn] |
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| | Opfermann, Nils [VerfasserIn] |
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| | Hörner-Rieber, Juliane [VerfasserIn] |
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| | Kappes, Jutta [VerfasserIn] |
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| | Thomas, Michael [VerfasserIn] |
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| | Bischoff, Helge [VerfasserIn] |
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| | Herth, Felix [VerfasserIn] |
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| | Heußel, Claus Peter [VerfasserIn] |
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| | Debus, Jürgen [VerfasserIn] |
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| | Steins, Martin [VerfasserIn] |
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| | Rieken, Stefan [VerfasserIn] |
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| Titel: | Nine-year experience |
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| Titelzusatz: | prophylactic cranial irradiation in extensive disease small-cell lung cancer |
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| Verf.angabe: | Denise Bernhardt, Sebastian Adeberg, Farastuk Bozorgmehr, Nils Opfermann, Juliane Hoerner-Rieber, Michael C. Repka, Jutta Kappes, Michael Thomas, Helge Bischoff, Felix Herth, Claus Peter Heußel, Jürgen Debus, Martin Steins, Stefan Rieken |
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| Jahr: | 2017 |
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| Jahr des Originals: | 2016 |
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| Umfang: | 5 S. |
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| Fussnoten: | Gesehen am 24.05.2018 ; Epub: Dec 2, 2016 |
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| Titel Quelle: | Enthalten in: Clinical lung cancer |
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| Ort Quelle: | Dallas, Tex. : Cancer Information Group, 1999 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 18(2017), 4, Seite e267-e271 |
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| ISSN Quelle: | 1938-0690 |
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| Abstract: | Background In 2007, the European Organization for Research and Treatment of Cancer (EORTC) study (ClinicalTrials.gov identifier, NCT00016211) demonstrated a beneficial effect on overall survival (OS) with the use of prophylactic cranial irradiation (PCI) for extensive disease (ED) small-cell lung cancer (SCLC). Nevertheless, debate is ongoing regarding the role of PCI, because the patients in that trial did not undergo magnetic resonance imaging (MRI) of the brain before treatment. Also, a recent Japanese randomized trial showed a detrimental effect of PCI on OS in patients with negative pretreatment brain MRI findings. Materials and Methods We examined the medical records of 136 patients with ED SCLC who had initially responded to chemotherapy and undergone PCI from 2007 to 2015. The outcomes, radiation toxicity, neurologic progression-free survival, and OS after PCI were analyzed. Survival and correlations were calculated using log-rank and univariate Cox proportional hazard ratio analyses. Results The median OS and the median neurologic progression-free survival after PCI was 12 and 19 months, respectively. No significant survival difference was seen for patients who had undergone MRI before PCI compared with patients who had undergone contrast-enhanced computed tomography (P = .20). Univariate analysis for OS did not show a statistically significant effect for known cofactors. Conclusion In the present cohort, PCI was associated with improved survival compared with the PCI arm of the EORTC trial, with a nearly doubled median OS period. Also, the median OS was prolonged by 2 months compared with the irradiation arm of the Japanese trial. |
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| DOI: | doi:10.1016/j.cllc.2016.11.012 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1016/j.cllc.2016.11.012 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S1525730416303667 |
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| | DOI: https://doi.org/10.1016/j.cllc.2016.11.012 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Brain metastasis |
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| | ED |
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| | PCI |
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| | SCLC |
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| | Survival |
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| K10plus-PPN: | 1575455064 |
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| Verknüpfungen: | → Zeitschrift |
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