Hepatitis C virus and human cytomegalovirus - natural killer cell subsets in persistent viral infections

• Verfasst von: Pollmann, Julia [VerfasserIn]
• Verfasst von: Rölle, Alexander [VerfasserIn]
• Verfasst von: Hofmann, Maike [VerfasserIn]
• Verfasst von: Cerwenka, Adelheid [VerfasserIn]
• Titel: Hepatitis C virus and human cytomegalovirus - natural killer cell subsets in persistent viral infections
• Verf.angabe: Julia Pollmann, Alexander Rölle, Maike Hofmann, Adelheid Cerwenka
• E-Jahr: 2017
• Jahr: 17 May 2017
• Umfang: 8 S.
• Fussnoten: Gesehen am 24.05.2018
• Titel Quelle: Enthalten in: Frontiers in immunology
• Ort Quelle: Lausanne : Frontiers Media, 2010
• Jahr Quelle: 2017
• Band/Heft Quelle: 8(2017) Artikel-Nummer 566, 8 Seiten
• ISSN Quelle: 1664-3224
• DOI: doi:10.3389/fimmu.2017.00566
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Chronic infection
• Sach-SW: hcmv
• Sach-SW: HCV
• Sach-SW: Natural Killer cells
• Sach-SW: NK subsets
• K10plus-PPN: 1575461498

Abstract

Hepatitis C Virus (HCV) and Human Cytomegalovirus (HCMV) are two prominent examples of RNA and DNA viruses, respectively that establish a persistent infection of their host. HCV affects over 185 million patients worldwide, who are at high risk for developing liver fibrosis, liver cirrhosis and ultimately hepatocellular carcinoma. Recent breakthroughs in HCV therapy, using direct-acting antivirals (DAA) have provided the opportunity to monitor NK cells after clearance of a chronic infection. There is now increasing evidence that the individual NK cell repertoire before infection is predictive for the course of disease. HCMV affects the majority of the global population. While being asymptomatic in healthy individuals, HCMV represents a severe clinical challenge in immunocompromised patients. Both viral infections, HCV and HCMV, lead to long-lasting and profound alterations within the entire NK cell compartment. This review article, will discuss the diverse range of changes in the NK cell compartment as well as potential consequences for the course of disease.