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Verfasst von:Niklas, Martin Anthony [VerfasserIn]   i
 Jäkel, Oliver [VerfasserIn]   i
 Abdollahi, Amir [VerfasserIn]   i
Titel:STED microscopy visualizes energy deposition of single ions in a solid-state detector beyond diffraction limit
Verf.angabe:M. Niklas, M. Henrich, O. Jäkel, J. Engelhardt, A. Abdollahi, S. Greilich
E-Jahr:2017
Jahr:5 April 2017
Umfang:11 S.
Teil:volume:62
 year:2017
 number:9
 pages:N180-N190
 extent:11
Fussnoten:Gesehen am 28.05.2018
Titel Quelle:Enthalten in: Physics in medicine and biology
Ort Quelle:Bristol : IOP Publ., 1956
Jahr Quelle:2017
Band/Heft Quelle:62(2017), 9, Seite N180-N190
ISSN Quelle:1361-6560
Abstract:Fluorescent nuclear track detectors (FNTDs) allow for visualization of single-particle traversal in clinical ion beams. The point spread function of the confocal readout has so far hindered a more detailed characterization of the track spots—the ion’s characteristic signature left in the FNTD. Here we report on the readout of the FNTD by optical nanoscopy, namely stimulated emission depletion microscopy. It was firstly possible to visualize the track spots of carbon ions and protons beyond the diffraction limit of conventional light microscopy with a resolving power of approximately 80 nm (confocal: 320 nm). A clear discrimination of the spatial width, defined by the full width half maximum of track spots from particles (proton and carbon ions), with a linear energy transfer (LET) ranging from approximately 2-1016 keV µ m −1 was possible. Results suggest that the width depends on LET but not on particle charge within the uncertainties. A discrimination of particle type by width thus does not seem possible (as well as with confocal microscopy). The increased resolution, however, could allow for refined determination of the cross-sectional area facing substantial energy deposition. This work could pave the way towards development of optical nanoscopy-based analysis of radiation-induced cellular response using cell-fluorescent ion track hybrid detectors.
DOI:doi:10.1088/1361-6560/aa5edc
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1088/1361-6560/aa5edc
 Volltext: http://stacks.iop.org/0031-9155/62/i=9/a=N180
 DOI: https://doi.org/10.1088/1361-6560/aa5edc
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1575546213
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