| |  Online-Ressource |
|---|
| Verfasst von: | Ryl, Tatsiana [VerfasserIn]  |
|---|
| | Kuchen, Erika [VerfasserIn] |
|---|
| | Shao, Chunxuan [VerfasserIn] |
|---|
| | Flórez, Andrés [VerfasserIn] |
|---|
| | Mönke, Gregor [VerfasserIn] |
|---|
| | Lamprecht, Florian [VerfasserIn] |
|---|
| | Höfer, Thomas [VerfasserIn] |
|---|
| Titel: | Cell-cycle position of single MYC-driven cancer cells dictates their susceptibility to a chemotherapeutic drug |
|---|
| Verf.angabe: | Tatsiana Ryl, Erika E. Kuchen, Emma Bell, Chunxuan Shao, Andrés F. Flórez, Gregor Mönke, Sina Gogolin, Mona Friedrich, Florian Lamprecht, Frank Westermann, Thomas Höfer |
|---|
| E-Jahr: | 2017 |
|---|
| Jahr: | 23 August 2017 |
|---|
| Umfang: | 22 S. |
|---|
| Fussnoten: | Gesehen am 28.05.2018 ; Available online 23 August 2017 |
|---|
| Titel Quelle: | Enthalten in: Cell systems |
|---|
| Ort Quelle: | Maryland Heights, MO : Elsevier, 2015 |
|---|
| Jahr Quelle: | 2017 |
|---|
| Band/Heft Quelle: | 5(2017,3) Seite 237-250, e1-e8, 22 Seiten |
|---|
| ISSN Quelle: | 2405-4720 |
|---|
| Abstract: | Summary: While many tumors initially respond to chemotherapy, regrowth of surviving cells compromises treatment efficacy in the long term. The cell-biological basis of this regrowth is not understood. Here, we characterize the response of individual, patient-derived neuroblastoma cells driven by the prominent oncogene MYC to the first-line chemotherapy, doxorubicin. Combining live-cell imaging, cell-cycle-resolved transcriptomics, and mathematical modeling, we demonstrate that a cell's treatment response is dictated by its expression level of MYC and its cell-cycle position prior to treatment. All low-MYC cells enter therapy-induced senescence. High-MYC cells, by contrast, disable their cell-cycle checkpoints, forcing renewed proliferation despite treatment-induced DNA damage. After treatment, the viability of high-MYC cells depends on their cell-cycle position during treatment: newborn cells promptly halt in G1 phase, repair DNA damage, and form re-growing clones; all other cells show protracted DNA repair and ultimately die. These findings demonstrate that fast-proliferating tumor cells may resist cytotoxic treatment non-genetically, by arresting within a favorable window of the cell cycle. |
|---|
| DOI: | doi:10.1016/j.cels.2017.07.005 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: http://dx.doi.org/10.1016/j.cels.2017.07.005 |
|---|
| | Volltext: http://www.sciencedirect.com/science/article/pii/S2405471217303319 |
|---|
| | DOI: https://doi.org/10.1016/j.cels.2017.07.005 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | bistability |
|---|
| | cancer |
|---|
| | cell-cycle checkpoints |
|---|
| | cell-cycle-resolved transcriptomics |
|---|
| | live-cell imaging |
|---|
| | mathematical modeling |
|---|
| | MYC |
|---|
| | therapy resistance |
|---|
| K10plus-PPN: | 1575562553 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Cell-cycle position of single MYC-driven cancer cells dictates their susceptibility to a chemotherapeutic drug / Ryl, Tatsiana [VerfasserIn]; 23 August 2017 (Online-Ressource)
