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Verfasst von:Rheinheimer, Stephan [VerfasserIn]   i
 Pahernik, Sascha [VerfasserIn]   i
 Kauczor, Hans-Ulrich [VerfasserIn]   i
 Hallscheidt, Peter [VerfasserIn]   i
Titel:Investigation of renal lesions by diffusion-weighted magnetic resonance imaging applying intravoxel incoherent motion-derived parameters
Titelzusatz:initial experience
Verf.angabe:S. Rheinheimer, B. Stieltjes, F. Schneider, D. Simon, S. Pahernik, H.U. Kauczor, P. Hallscheidt
Jahr des Originals:2011
Umfang:7 S.
Fussnoten:Available online 20 November 2011 ; Gesehen am 28.05.2018
Titel Quelle:Enthalten in: European journal of radiology
Jahr Quelle:2012
Band/Heft Quelle:81(2012), 3, S. e310-e316
ISSN Quelle:1872-7727
Abstract:Purpose Usefulness of biexponentially fitted signal attenuation at different b-values for differentiating the histological characteristics of renal tumors. Materials and methods A total of 26 patients with 28 renal masses (histologically proven: 20 clear cell renal cell carcinomas [ccRCC], three transitional cell carcinomas, two oncocytomas, and one papillary RCC) and 30 volunteers with healthy kidneys were examined at 1.5Tesla using an echo-planar DWI sequence. Using the IVIM model, we calculated the perfusion fraction f and the diffusion coefficient D. Furthermore, the ADC was obtained. These tumor parameters were compared to healthy renal tissue nonparametrically, and a receiver operating characteristic (ROC) analysis was performed. Results Healthy renal parenchyma showed higher ADC and D values (p<0.001) than ccRCC (ADC 1.95±0.10 [SD]μm2/ms, f 18.32±2.52%, and D 1.88±0.11μm2/ms versus ADC 1.45±0.38μm2/ms, f 18.59±6.16%, and D 1.34±0.38μm2/ms). When detecting malignancies the area under the curve for D was higher than for ADC. The f values for ccRCC were higher (p<0.001) than for non-ccRCC (ADC 1.52±0.47μm2/ms, f 8.44±1.24%, and D 1.30±0.18μm2/ms). Both f and D correlated with ccRCC grading. Conclusion IVIM imaging is able to provide reliable diffusion values in the human kidney and may enhance the accuracy of tumor diagnosis. The D value was the best parameter to distinguish renal tumors from healthy renal tissue. The f value is promising for determining the histological subgroups.
DOI:doi:10.1016/j.ejrad.2011.10.016
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Verlag: http://dx.doi.org/10.1016/j.ejrad.2011.10.016
 Verlag: http://www.sciencedirect.com/science/article/pii/S0720048X11007595
 DOI: https://doi.org/10.1016/j.ejrad.2011.10.016
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1575784599
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