| Online-Ressource |
Verfasst von: | Rheinheimer, Stephan [VerfasserIn]  |
| Pahernik, Sascha [VerfasserIn]  |
| Kauczor, Hans-Ulrich [VerfasserIn]  |
| Hallscheidt, Peter [VerfasserIn]  |
Titel: | Investigation of renal lesions by diffusion-weighted magnetic resonance imaging applying intravoxel incoherent motion-derived parameters |
Titelzusatz: | initial experience |
Verf.angabe: | S. Rheinheimer, B. Stieltjes, F. Schneider, D. Simon, S. Pahernik, H.U. Kauczor, P. Hallscheidt |
Jahr des Originals: | 2011 |
Umfang: | 7 S. |
Fussnoten: | Available online 20 November 2011 ; Gesehen am 28.05.2018 |
Titel Quelle: | Enthalten in: European journal of radiology |
Jahr Quelle: | 2012 |
Band/Heft Quelle: | 81(2012), 3, S. e310-e316 |
ISSN Quelle: | 1872-7727 |
Abstract: | Purpose Usefulness of biexponentially fitted signal attenuation at different b-values for differentiating the histological characteristics of renal tumors. Materials and methods A total of 26 patients with 28 renal masses (histologically proven: 20 clear cell renal cell carcinomas [ccRCC], three transitional cell carcinomas, two oncocytomas, and one papillary RCC) and 30 volunteers with healthy kidneys were examined at 1.5Tesla using an echo-planar DWI sequence. Using the IVIM model, we calculated the perfusion fraction f and the diffusion coefficient D. Furthermore, the ADC was obtained. These tumor parameters were compared to healthy renal tissue nonparametrically, and a receiver operating characteristic (ROC) analysis was performed. Results Healthy renal parenchyma showed higher ADC and D values (p<0.001) than ccRCC (ADC 1.95±0.10 [SD]μm2/ms, f 18.32±2.52%, and D 1.88±0.11μm2/ms versus ADC 1.45±0.38μm2/ms, f 18.59±6.16%, and D 1.34±0.38μm2/ms). When detecting malignancies the area under the curve for D was higher than for ADC. The f values for ccRCC were higher (p<0.001) than for non-ccRCC (ADC 1.52±0.47μm2/ms, f 8.44±1.24%, and D 1.30±0.18μm2/ms). Both f and D correlated with ccRCC grading. Conclusion IVIM imaging is able to provide reliable diffusion values in the human kidney and may enhance the accuracy of tumor diagnosis. The D value was the best parameter to distinguish renal tumors from healthy renal tissue. The f value is promising for determining the histological subgroups. |
DOI: | doi:10.1016/j.ejrad.2011.10.016 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Verlag: http://dx.doi.org/10.1016/j.ejrad.2011.10.016 |
| Verlag: http://www.sciencedirect.com/science/article/pii/S0720048X11007595 |
| DOI: https://doi.org/10.1016/j.ejrad.2011.10.016 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1575784599 |
Verknüpfungen: | → Zeitschrift |
Investigation of renal lesions by diffusion-weighted magnetic resonance imaging applying intravoxel incoherent motion-derived parameters / Rheinheimer, Stephan [VerfasserIn] (Online-Ressource)