Aqueous microwave-assisted one-pot synthesis of N-substituted rhodanines

• Verfasst von: Nitsche, Christoph [VerfasserIn]
• Verfasst von: Klein, Christian D. [VerfasserIn]
• Titel: Aqueous microwave-assisted one-pot synthesis of N-substituted rhodanines
• Verf.angabe: Christoph Nitsche, Christian D. Klein
• Umfang: 5 S.
• Fussnoten: Gesehen am 29.05.2018
• Titel Quelle: Enthalten in: Tetrahedron letters
• Jahr Quelle: 2012
• Band/Heft Quelle: 53(2012), 39, S. 5197-5201
• ISSN Quelle: 1873-3581
• DOI: doi:10.1016/j.tetlet.2012.07.002
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1575802953

Abstract

Two aqueous, one-pot, microwave-assisted methods for the rapid synthesis of N-substituted rhodanines from amine substrates are described. Alkyl- and benzylamines could be converted into the corresponding rhodanines with an atom-efficient one-pot, three-step protocol based on carbon disulfide and chloroacetic acid in short reaction times and good to excellent yields. An alternative, microwave-assisted one-pot, one-step protocol using bis(carboxymethyl)trithiocarbonate in water was developed for the synthesis of N-arylrhodanines from anilines.