| |  Online-Ressource |
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| Verfasst von: | Ludwig, Ralf [VerfasserIn]  |
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| | Kaya, Ziya [VerfasserIn] |
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| | Fischer, Andrea [VerfasserIn] |
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| Titel: | Mechanisms of autoantibody-induced pathology |
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| Verf.angabe: | Ralf J. Ludwig, Karen Vanhoorelbeke, Frank Leypoldt, Ziya Kaya, Katja Bieber, Sandra M. McLachlan, Lars Komorowski, Jie Luo, Otavio Cabral-Marques, Christoph M. Hammers, Jon M. Lindstrom, Peter Lamprecht, Andrea Fischer, Gabriela Riemekasten, Claudia Tersteeg, Peter Sondermann, Basil Rapoport, Klaus-Peter Wandinger, Christian Probst, Asmaa El Beidaq, Enno Schmidt, Alan Verkman, Rudolf A. Manz, Falk Nimmerjahn |
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| E-Jahr: | 2017 |
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| Jahr: | 31 May 2017 |
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| Umfang: | 42 S. |
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| Fussnoten: | Gesehen am 29.05.2018 |
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| Titel Quelle: | Enthalten in: Frontiers in immunology |
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| Ort Quelle: | Lausanne : Frontiers Media, 2010 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 8(2017) Artikel-Nummer 603, 42 Seiten |
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| ISSN Quelle: | 1664-3224 |
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| Abstract: | Autoantibodies are frequently observed in healthy individuals. In a minority of these individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis or Graves’ disease. Overall, more than 2.5% of the population is affected by autoantibody-driven autoimmune disease. Pathways leading to autoantibody-induced pathology greatly differ among different diseases, and autoantibodies directed against the same antigen, depending on the targeted epitope, can have diverse effects. To foster knowledge in autoantibody-induced pathology and to encourage development of urgently needed novel therapeutic strategies we here categorized autoantibodies according to their effects. According to our algorithm, autoantibodies can be classified into the following categories: (1) Mimic receptor stimulation, (2) blocking of neural transmission, (3) induction of altered signaling, triggering uncontrolled (4) microthrombosis, (5) cell lysis, (6) neutrophil activation and (7) induction of inflammation. These mechanisms in relation to disease, as well as principles of autoantibody generation and detection are reviewed herein. |
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| DOI: | doi:10.3389/fimmu.2017.00603 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Kostenfrei: Volltext ; Verlag: http://dx.doi.org/10.3389/fimmu.2017.00603 |
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| | Kostenfrei: Volltext: https://www.frontiersin.org/articles/10.3389/fimmu.2017.00603/full |
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| | DOI: https://doi.org/10.3389/fimmu.2017.00603 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | ADAMTS13 |
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| | ANCA-associated vasculitis |
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| | Anti-NMDA encephalitis |
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| | aquaporin-4 (AQP4) |
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| | Autoantibodies |
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| | Autoantibody-induced carditis |
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| | autoimmune hemolytic anemia |
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| | Autoimmunity |
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| | B cells |
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| | Bullous |
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| | diagnosis |
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| | Epidermolysis Bullosa Acquisita |
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| | Goodpasture’s |
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| | Grave’s disease |
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| | idiopathic thrombocytopenic purpura |
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| | immunofluorescence microscopy |
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| | mouse models |
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| | multiplexing |
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| | Myasthenia Gravis |
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| | Neuromyelitis optica spectrum disorder |
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| K10plus-PPN: | 157580722X |
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| Verknüpfungen: | → Zeitschrift |
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Mechanisms of autoantibody-induced pathology / Ludwig, Ralf [VerfasserIn]; 31 May 2017 (Online-Ressource)
