Peroxisome morphology in pathology

• Verfasst von: Ribeiro, Daniela [VerfasserIn]
• Verfasst von: Fahimi, H. Dariush [VerfasserIn]
• Titel: Peroxisome morphology in pathology
• Verf.angabe: Daniela Ribeiro, Inês Castro, H. Dariush Fahimi and Michael Schrader
• Umfang: 6 S.
• Fussnoten: Gesehen am 29.05.2018
• Titel Quelle: Enthalten in: Histology and histopathology
• Jahr Quelle: 2012
• Band/Heft Quelle: 27(2012), 6, S. 661-676
• ISSN Quelle: 1699-5848
• DOI: doi:10.14670/HH-27.661
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1575814307

Abstract

Peroxisomes are remarkably dynamic and versatile organelles that are essential for human health and development. They respond to physiological changes in the cellular environment by adapting their morphology, number, enzyme content and metabolic functions accordingly. With the discovery of the first key peroxisomal morphology proteins, the investigation of peroxisomal shape, distribution and dynamics has become an exciting new field in cell biology and biomedical sciences because of its relation to organelle functionality and its impact on developmental and physiological processes. In this review, we summarize recent findings on peroxisome biology, dynamics and the modulation of peroxisome morphology, especially in mammals. Furthermore, we discuss the roles of peroxisome dynamics and morphology in cell pathology and present recent examples for alterations in peroxisome morphology under disease conditions. Besides defects in the peroxisomal morphology machinery, we also address peroxisome biogenesis disorders, alterations of peroxisome number during carcinogenesis and liver cirrhosis, and morphological alterations of peroxisomes during viral infection.