Changing the tumor microenvironment

• Verfasst von: Berraondo, Pedro [VerfasserIn]
• Verfasst von: Umansky, Viktor [VerfasserIn]
• Verfasst von: Melero, Ignacio [VerfasserIn]
• Titel: Changing the tumor microenvironment
• Titelzusatz: new strategies for immunotherapy
• Verf.angabe: Pedro Berraondo, Viktor Umansky, and Ignacio Melero
• E-Jahr: 2012
• Jahr: July 23, 2012
• Umfang: 6 S.
• Fussnoten: Gesehen am 30.05.2018
• Titel Quelle: Enthalten in: Cancer research
• Ort Quelle: Philadelphia, Pa. : AACR, 1916
• Jahr Quelle: 2012
• Band/Heft Quelle: 72(2012), 20, Seite 5159-5164
• ISSN Quelle: 1538-7445
• DOI: doi:10.1158/0008-5472.CAN-12-1952
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1575841835

Abstract

Solid tumors are composed of malignant cells surrounded by a tumor-conditioned stroma that contains extracellular matrix and a variety of nonmalignant populations, including myeloid cells, lymphocytes, fibroblasts, and endothelial cells. These stromal elements form a local immunoregulatory network that must be overcome to achieve eradication of established tumors by immunotherapy. On March 21-22, 2012, a symposium was held in Pamplona, Spain, to share the recent advances regarding the molecules and cells that create and sustain this immune-hostile tumor microenvironment. Excellent targets for immunotherapeutic intervention were identified, and a number of therapeutic strategies under translation from mouse to human were presented. Cancer Res; 72(20); 5159-64. ©2012 AACR.