| |  Online-Ressource |
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| Verfasst von: | Fuchs, Tina [VerfasserIn]  |
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| | Riabov, Vladimir [VerfasserIn] |
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| | Yin, Shuiping [VerfasserIn] |
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| | Kzhyshkowska, Julia [VerfasserIn] |
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| | Busch, Svenja [VerfasserIn] |
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| | Neumaier, Michael [VerfasserIn] |
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| | Kaminski, Wolfgang E. [VerfasserIn] |
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| Titel: | A combinatorial αβ T cell receptor expressed by macrophages in the tumor microenvironment |
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| Verf.angabe: | Tina Fuchs, Martin Hahn, Vladimir Riabov, Shuiping Yin, Julia Kzhyshkowska, Svenja Busch, Kerstin Püllmann, Alexander W. Beham, Michael Neumaier, Wolfgang E. Kaminski |
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| Jahr: | 2017 |
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| Jahr des Originals: | 2015 |
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| Umfang: | 6 S. |
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| Fussnoten: | Available online 20 October 2015 ; Gesehen am 24.08.2021 |
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| Titel Quelle: | Enthalten in: Immunobiology |
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| Ort Quelle: | München : Elsevier, 1979 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 222(2017), 1, Seite 39-44 |
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| ISSN Quelle: | 1878-3279 |
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| Abstract: | Recent evidence indicates the presence of macrophage subpopulations that express the TCRαβ in two major inflammatory diseases, tuberculosis and atherosclerosis. Inflammation is also a well-established attribute of cancer progression and macrophages are one of the major immune cells that infiltrate tumors. Here, we demonstrate that the macrophage-TCRαβ is expressed in the tumor microenvironment of human and murine malignancies. We identify TCRαβ+ macrophages in each case of four randomly selected distinct human tumor entities. In human tumor tissues, the TCRαβ expressed by macrophages in the tumor microenvironment is a combinatorial and individual-specific immune receptor. Furthermore, we routinely find TCRαβ+ macrophage subpopulations in experimental tumors (TS/A, mammary adenocarcinoma) which we induced both in normal mice and mice deficient in the macrophage receptor stabilin-1. Expression of the combinatorial murine tumor macrophage TCRαβ is individual-specific and independent of stabilin-1. These results demonstrate that TCRαβ expression is a characteristic feature of macrophages in the tumor microenvironment and identify an as yet unrecognized flexible element in the macrophage-based host response to tumors. |
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| DOI: | doi:10.1016/j.imbio.2015.09.022 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1016/j.imbio.2015.09.022 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0171298515300735 |
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| | DOI: https://doi.org/10.1016/j.imbio.2015.09.022 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Macrophages in the tumor microenvironment |
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| | TCRαβ |
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| | Variable immune receptor |
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| K10plus-PPN: | 1575896605 |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ combinatorial αβ T cell receptor expressed by macrophages in the tumor microenvironment / Fuchs, Tina [VerfasserIn]; 2017 (Online-Ressource)
