Corticosteroid resistance in sepsis is influenced by microRNA-124-induced downregulation of glucocorticoid receptor-α*

• Verfasst von: Ledderose, Carola [VerfasserIn]
• Titel: Corticosteroid resistance in sepsis is influenced by microRNA-124-induced downregulation of glucocorticoid receptor-α*
• Verf.angabe: Carola Ledderose, Patrick Möhnle, Elisabeth Limbeck, Stefanie Schütz, Florian Weis, Jessica Rink, Josef Briegel, Simone Kreth
• E-Jahr: 2012
• Jahr: 2012/10/01
• Umfang: 9 S.
• Fussnoten: Gesehen am 04.06.2018
• Titel Quelle: Enthalten in: Critical care medicine
• Ort Quelle: Hagerstown, Md. : Lippincott Williams & Wilkins, 1973
• Jahr Quelle: 2012
• Band/Heft Quelle: 40(2012), 10, Seite 2745-2753
• ISSN Quelle: 1530-0293
• DOI: doi:10.1097/CCM.0b013e31825b8ebc
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1575918692

Abstract

Acquired glucocorticoid resistance frequently complicates the therapy of sepsis. It leads to an exaggerated proinflammatory response and has been related to altered expression profiles of glucocorticoid receptor isoforms glucocorticoid receptor-α (mediating anti-inflammatory effects) and glucocorticoid receptor-β (acting as a dominant negative inhibitor). We investigated the impact of glucocorticoid receptor isoforms on glucocorticoid effects in human T-cells. We hypothesized that 1) changes of the ratio of glucocorticoid receptor isoforms impact glucocorticoid resistance and 2) glucocorticoid receptor-α expression is controlled by microRNA-mediated gene silencing.