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Status: Bibliographieeintrag

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Verfasst von:Andreiuolo, Felipe [VerfasserIn]   i
 Witt, Hendrik [VerfasserIn]   i
 Korshunov, Andrey [VerfasserIn]   i
 Pfister, Stefan [VerfasserIn]   i
Titel:Integrating Tenascin-C protein expression and 1q25 copy number status in pediatric intracranial ependymoma prognostication
Titelzusatz:a new model for risk stratification
Verf.angabe:Felipe Andreiuolo, Gwénaël Le Teuff, Mohamed Amine Bayar, John-Paul Kilday, Torsten Pietsch, André O. von Bueren, Hendrik Witt, Andrey Korshunov, Piergiorgio Modena, Stefan M. Pfister, Mélanie Pagès, David Castel, Felice Giangaspero, Leila Chimelli, Pascale Varlet, Stefan Rutkowski, Didier Frappaz, Maura Massimino, Richard Grundy, Jacques Grill, on behalf of the SIOP Ependymoma Biology Working Group BIOMECA (BIOlogical Markers for Ependymomas in Children and Adolescents)
E-Jahr:2017
Jahr:June 15, 2017
Umfang:17 S.
Fussnoten:Gesehen am 06.06.2018
Titel Quelle:Enthalten in: PLOS ONE
Ort Quelle:San Francisco, California, US : PLOS, 2006
Jahr Quelle:2017
Band/Heft Quelle:12(2017,6) Artikel-Nummer e0178351, 17 Seiten
ISSN Quelle:1932-6203
Abstract:PURPOSE: Despite multimodal therapy, prognosis of pediatric intracranial ependymomas remains poor with a 5-year survival rate below 70% and frequent late deaths. EXPERIMENTAL DESIGN: This multicentric European study evaluated putative prognostic biomarkers. Tenascin-C (TNC) immunohistochemical expression and copy number status of 1q25 were retained for a pooled analysis of 5 independent cohorts. The prognostic value of TNC and 1q25 on the overall survival (OS) was assessed using a Cox model adjusted to age at diagnosis, tumor location, WHO grade, extent of resection, radiotherapy and stratified by cohort. Stratification on a predictor that did not satisfy the proportional hazards assumption was considered. Model performance was evaluated and an internal-external cross validation was performed. RESULTS: Among complete cases with 5-year median follow-up (n = 470; 131 deaths), TNC and 1q25 gain were significantly associated with age at diagnosis and posterior fossa tumor location. 1q25 status added independent prognostic value for death beyond the classical variables with a hazard ratio (HR) = 2.19 95%CI = [1.29; 3.76] (p = 0.004), while TNC prognostic relation was tumor location-dependent with HR = 2.19 95%CI = [1.29; 3.76] (p = 0.004) in posterior fossa and HR = 0.64 [0.28; 1.48] (p = 0.295) in supratentorial (interaction p value = 0.015). The derived prognostic score identified 3 different robust risk groups. The omission of upfront RT was not associated with OS for good and intermediate prognostic groups while the absence of upfront RT was negatively associated with OS in the poor risk group. CONCLUSION: Integrated TNC expression and 1q25 status are useful to better stratify patients and to eventually adapt treatment regimens in pediatric intracranial ependymoma.
DOI:doi:10.1371/journal.pone.0178351
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Kostenfrei: Volltext: http://dx.doi.org/10.1371/journal.pone.0178351
 DOI: https://doi.org/10.1371/journal.pone.0178351
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Age of Onset
 Child
 Child, Preschool
 Chromosomes, Human, Pair 1
 DNA Copy Number Variations
 Ependymoma
 Female
 Humans
 Infant
 Male
 Prognosis
 Survival Analysis
 Tenascin
K10plus-PPN:1576031179
Verknüpfungen:→ Zeitschrift

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