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Status: Bibliographieeintrag

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Verfasst von:Schmieder, Astrid [VerfasserIn]   i
 Schledzewski, Kai [VerfasserIn]   i
 Michels-Zetsche, Julia D. [VerfasserIn]   i
 Schönhaar, Kathrin [VerfasserIn]   i
 Sauer, Andrea [VerfasserIn]   i
 Sticht, Carsten [VerfasserIn]   i
 Géraud, Cyrill [VerfasserIn]   i
 Goerdt, Sergij [VerfasserIn]   i
Titel:The CD20 homolog Ms4a8a integrates pro- and anti-inflammatory signals in novel M2-like macrophages and is expressed in parasite infection
Verf.angabe:Astrid Schmieder, Kai Schledzewski, Julia Michel, Kathrin Schönhaar, Yannick Morias, Tom Bosschaerts, Jan Van den Bossche, Pierre Dorny, Andrea Sauer, Carsten Sticht, Cyrill Géraud, Zoe Waibler, Alain Beschin and Sergij Goerdt
E-Jahr:2012
Jahr:18 July 2012
Umfang:12 S.
Fussnoten:Gesehen am 06.06.2018
Titel Quelle:Enthalten in: European journal of immunology
Ort Quelle:Weinheim : Wiley-VCH, 1971
Jahr Quelle:2012
Band/Heft Quelle:42(2012), 11, Seite 2971-2982
ISSN Quelle:1521-4141
Abstract:Recently, we identified the CD20 homolog Ms4a8a as a novel molecule expressed by tumor-associated macrophages that directly enhances tumor growth. Here, we analyzed Ms4a8a+ macrophages in M2-associated infectious pathologies. In late-stage Trypanosoma congolense and Taenia crassiceps infections, Ms4a8a expression was detected in hepatic and peritoneal macrophages respectively. Innate immunity in these infections is modulated by Toll-like receptor (TLR) signaling and TLR2/4/7 agonists strongly induced Ms4a8a expression in bone marrow derived macrophages (BMDMs) treated with M2 mediators (glucocorticoids/IL-4). LPS/dexamethasone/IL-4-induced Ms4a8a+ BMDMs were characterized by strong expression of mRNA of mannose receptor (Mmr), arginase 1, and CD163, and by decreased iNOS expression. Coinduction of Ms4a8a by M2 mediators and TLR agonists involved the classical TLR signaling cascade via activation of MyD88/TRIF and NF-κB. Forced overexpression of Ms4a8a modulated the TLR4 response of RAW264.7 cells as shown by gene expression profiling. Upregulation of Hdc, Tcfec, and Sla was confirmed both in primary LPS/dexamethasone/IL-4-stimulated Ms4a8a+ BMDMs and in peritoneal macrophages from late-stage Taenia crassiceps infection. In conclusion, we show that TLR signaling skews the typical alternative macrophage activation program to induce a special M2-like macrophage subset in vitro that also occurs in immunomodulatory immune reactions in vivo, a process directly involving the CD20 homolog Ms4a8a.
DOI:doi:10.1002/eji.201142331
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: http://dx.doi.org/10.1002/eji.201142331
 kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.201142331
 DOI: https://doi.org/10.1002/eji.201142331
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Alternative macrophage activation
 CD20 homolog
 Parasitic infection
 Toll-like receptor
K10plus-PPN:1576105490
Verknüpfungen:→ Zeitschrift

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