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Verfasst von:Schwarzbich, Mark-Alexander [VerfasserIn]   i
 Witzens-Harig, Mathias [VerfasserIn]   i
Titel:Cellular immunotherapy in B-cell malignancy
Verf.angabe:Mark-Alexander Schwarzbich, Mathias Witzens-Harig
Umfang:8 S.
Fussnoten:Gesehen am 06.06.2018
Titel Quelle:Enthalten in: Oncology research and treatment
Jahr Quelle:2017
Band/Heft Quelle:40(2017), 11, S. 674-681
ISSN Quelle:2296-5262
Abstract:In recent years, cellular immunotherapy in B-cell malignancies has been driven by adoptive transfer of genetically engineered T cells expressing chimeric antigen receptors (CARs). CARs consist of a single chain variable fragment (scFv) of a monoclonal antibody, a spacer domain, a transmembrane domain, an intracellular signaling domain, and additional costimulatory domains. The bulk of clinical data available is on CD19-targeting CAR T cells for the treatment of B-cell acute lymphocytic leukemia (B-ALL), chronic lymphocytic leukemia, and B-cell non-Hodgkin lymphoma. Results so far have been promising with impressive rates and depth of remission especially among B-ALL patients. However, CAR T-cell therapy is a complex multi-step process, and clinical trials so far differ profoundly in CAR construct used, gene transfer method, composition of the cellular product, lymphodepletion, and CAR T-cell dose used. Randomized trials will be needed to conclusively evaluate the implicationsof these differences. The treatment concept is associated with significant neurotoxicity and potentially lethal cytokine release syndrome, both of which require specific management. Improvements in CAR design may help to overcome toxicity, the effects of an immunosuppressive microenvironment, and tumor escape by development of antigen-negative clones. This review will explain the mechanism of action, summarize the clinical experience with this treatment modality so far, and explore future developments in the field.
DOI:doi:10.1159/000481946
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Verlag: http://dx.doi.org/10.1159/000481946
 Verlag: https://www.karger.com/Article/FullText/481946
 DOI: https://doi.org/10.1159/000481946
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1576111156
Verknüpfungen:→ Zeitschrift

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