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Verfasst von:Rinaldetti, Sébastien [VerfasserIn]   i
 Worst, Thomas [VerfasserIn]   i
 Weis, Cleo-Aron Thias [VerfasserIn]   i
 Erben, Philipp [VerfasserIn]   i
Titel:FOXM1 predicts overall and disease specific survival in muscle-invasive urothelial carcinoma and presents a differential expression between bladder cancer subtypes
Verf.angabe:Sebastien Rinaldetti, Ralph Markus Wirtz, Thomas Stefan Worst, Markus Eckstein, Cleo Aaron Weiss, Johannes Breyer, Wolfgang Otto, Christian Bolenz, Arndt Hartmann and Philipp Erben
E-Jahr:2017
Jahr:April 24, 2017
Umfang:12 S.
Fussnoten:Gesehen am 06.06.2018
Titel Quelle:Enthalten in: OncoTarget
Ort Quelle:[Erscheinungsort nicht ermittelbar] : Impact Journals LLC, 2010
Jahr Quelle:2017
Band/Heft Quelle:8(2017), 29, Seite 47595-47606
ISSN Quelle:1949-2553
Abstract:Forkhead box M1 (FOXM1) is a late cell cycle gene that plays a crucial role in carcinogenesis and chemotherapeutic drug resistance. In this study, the impact of FOXM1 expression on patient outcome was investigated for the first time in formalin fixed and paraffin embedded (FFPE) samples of chemotherapy naïve muscle-invasive bladder cancer (MIBC) patients. Expression analyses were performed on the Mannheim cohort (n=84) and validated on the independent Chungbuk cohort (n=61). In a Cox’ proportional hazards model, a distinct FOXM1 expression cut-off dividing both cohorts in a ‘high-risk’ and ‘low-risk’ group has been determined. Multivariate analyses showed that FOXM1 is an independent risk factor for outcome prediction superior to the TNM system. The FOXM1 ‘high-risk’ group had a 4- to 7-fold increased risk of death (p<0.03) and presented further an overexpression of MKI67. Recent studies showed that MIBCs can be subclassified in breast cancer-like subtypes: basal, luminal and p53-like. Here we demonstrated that FOXM1 was differentially expressed between MIBC subtypes concordant to its subtype specific expression in breast cancer. Since the proto-oncogene FOXM1 is known to play an important role in cisplatin resistance and to be a promising drug target, this study supports FOXM1 as a crucial biomarker in the personalization of MIBC therapy and urges prospective translational studies.
DOI:doi:10.18632/oncotarget.17394
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: http://dx.doi.org/10.18632/oncotarget.17394
 kostenfrei: Volltext: http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=17394&path[]=55649
 DOI: https://doi.org/10.18632/oncotarget.17394
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1576116883
Verknüpfungen:→ Zeitschrift

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