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Verfasst von:Takahashi, Tatiane T. [VerfasserIn]   i
 Vengeliene, Valentina [VerfasserIn]   i
 Spanagel, Rainer [VerfasserIn]   i
Titel:Melatonin reduces motivation for cocaine self-administration and prevents relapse-like behavior in rats
Verf.angabe:Tatiane T. Takahashi, Valentina Vengeliene, Rainer Spanagel
Jahr:2017
Umfang:8 S.
Fussnoten:First online: 28 February 2017 ; Gesehen am 08.06.2018
Titel Quelle:Enthalten in: Psychopharmacology
Ort Quelle:Berlin : Springer, 1959
Jahr Quelle:2017
Band/Heft Quelle:234(2017), 11, Seite 1741-1748
ISSN Quelle:1432-2072
Abstract:Rationale: Melatonin is a hormone involved in the entrainment of circadian rhythms, which appears dysregulated in drug users. Further, it has been demonstrated that melatonin can modulate the reinforcing effects of several drugs of abuse and may therefore play a role in drug addiction. Objective: Here, we investigated whether administration of melatonin reduces relapse-like behavior and the motivation to seek cocaine in rats. Methods: Male Sprague-Dawley rats were submitted to long-term cocaine self-administration training. Thereafter, melatonin effects were assessed on: (1) the motivation to work for cocaine in the break point test, (2) the relapse-like behavior in the cue-induced reinstatement test, (3) the distance traveled in the open field test, and (4) sucrose preference in a two-bottle choice paradigm. Melatonin, 25 or 50 mg/kg, was injected 3-4 h after the dark phase onset, 30 min prior to each test. Results: Both doses of melatonin decreased the number of active pokes in both break point and cue-induced reinstatement tests, demonstrating that melatonin can reduce the cocaine-seeking behavior and the motivation to work for cocaine. Administration of the higher dose of this hormone, however, significantly reduced the number of inactive pokes during the cue-induced reinstatement test and tended to reduce animals’ locomotor activity in the open field test. Sucrose preference was unchanged in both vehicle- and melatonin-treated animal groups. Conclusions: Our data suggest that melatonin administration may lower the risk of relapse triggered by cues in cocaine-experienced animals.
DOI:doi:10.1007/s00213-017-4576-y
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1007/s00213-017-4576-y
 Volltext: https://link-springer-com.ezproxy.medma.uni-heidelberg.de/article/10.1007/s00213-017-4576-y
 DOI: https://doi.org/10.1007/s00213-017-4576-y
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1576175898
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