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Verfasst von:Galata, Christian [VerfasserIn]   i
 Hirsch, Daniela [VerfasserIn]   i
 Reindl, Wolfgang [VerfasserIn]   i
 Post, Stefan [VerfasserIn]   i
 Kienle, Peter [VerfasserIn]   i
 Boutros, Michael [VerfasserIn]   i
 Gaiser, Timo [VerfasserIn]   i
 Horisberger, Karoline [VerfasserIn]   i
Titel:Clinical and histopathologic features of colorectal adenocarcinoma in Crohn’s disease
Verf.angabe:Christian Galata, MD, Daniela Hirsch, MD, Wolfgang Reindl, MD, Stefan Post, MD, Peter Kienle, MD, Michael Boutros, PhD, Timo Gaiser, MD, and Karoline Horisberger, MD
Jahr:2018
Umfang:6 S.
Fussnoten:Links funktionieren nicht ; Publish ahead of print 2017 ; Gesehen am 12.06.2018
Titel Quelle:Enthalten in: Journal of clinical gastroenterology
Ort Quelle:Philadelphia, Pa. : Lippincott Williams & Wilkins, 1979
Jahr Quelle:2018
Band/Heft Quelle:52(2018), 7, Seite 635-640
ISSN Quelle:1539-2031
Abstract:Goals: The aim of this study was to assess the histopathologic characteristics of colorectal carcinomas (CRC) in patients with Crohn’s disease (CD). Background: A higher frequency of microsatellite instability (MSI) is seen in mucinous compared with nonmucinous CRC which suggests that its pathogenesis involves distinct molecular pathways. Several publications reported a higher percentage of mucinous adenocarcinoma in CD patients with CRC. So far, there has been no investigation of MSI in CD patients with mucinous CRC. Study: The medical records of patients who underwent surgery for CRC were reviewed and those with a history of CD identified. The data of histologic classification and MSI status of the tumor were investigated.Results: Fourteen patients with CD-associated CRC were identified (5 female, 9 male) resulting in 20 CRC in total. Histologic investigation revealed 7 adenocarcinomas without a mucinous or signet ring cell component. All other CRCs harbored a mucinous (n=11) and/or signet ring cell (n=6) component. All tumors assessed for MSI were found to be microsatellite stable. Conclusions: Our data indicate that CRCs with signet ring cell and mucinous components were much more common in patients with CD than in patients with sporadic CRC. This observation suggests that CRC in CD represent an own entity with distinct histopathologic and molecular features. This may implicate potential consequences for diagnosis and therapy of CRC in CD in the future as well as new factors to identify patients with an increased risk for developing CRC in CD.
DOI:doi:10.1097/MCG.0000000000000817
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1097/MCG.0000000000000817
 Volltext: https://journals.lww.com/jcge/Abstract/publishahead/Clinical_and_Histopathologic_Features_of.98058.aspx
 DOI: https://doi.org/10.1097/MCG.0000000000000817
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1576261719
Verknüpfungen:→ Zeitschrift

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