Inattention and reaction time variability are linked to ventromedial prefrontal volume in adolescents

• Verfasst von: Albaugh, Matthew [VerfasserIn]
• Verfasst von: Banaschewski, Tobias [VerfasserIn]
• Verfasst von: Flor, Herta [VerfasserIn]
• Verfasst von: Poustka, Luise [VerfasserIn]
• Titel: Inattention and reaction time variability are linked to ventromedial prefrontal volume in adolescents
• Verf.angabe: Matthew D. Albaugh, Catherine Orr, Bader Chaarani, Robert R. Althoff, Nicholas Allgaier, Nicholas D’Alberto, Kelsey Hudson, Scott Mackey, Philip A. Spechler, Tobias Banaschewski, Rüdiger Brühl, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Anna Cattrell, Patricia J. Conrod, Sylvane Desrivières, Herta Flor, Vincent Frouin, Jürgen Gallinat, Robert Goodman, Penny Gowland, Yvonne Grimmer, Andreas Heinz, Viola Kappel, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Jani Penttila¨, Luise Poustka, Tomáš Paus, Michael N. Smolka, Maren Struve, Henrik Walter, Robert Whelan, Gunter Schumann, Hugh Garavan, Alexandra S. Potter
• Jahr: 2017
• Umfang: 9 S.
• Fussnoten: Available online 13 January 2017 ; Gesehen am 12.06.2018
• Titel Quelle: Enthalten in: Biological psychiatry
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1985
• Jahr Quelle: 2017
• Band/Heft Quelle: 82(2017), 9, Seite 660-668
• ISSN Quelle: 1873-2402
• DOI: doi:10.1016/j.biopsych.2017.01.003
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Attention-deficit/hyperactivity disorder
• Sach-SW: Inattention
• Sach-SW: Multi-informant
• Sach-SW: Neuroimaging
• Sach-SW: Reaction time variability
• Sach-SW: Ventromedial prefrontal cortex
• K10plus-PPN: 1576279588

Abstract

Background: Neuroimaging studies of attention-deficit/hyperactivity disorder (ADHD) have most commonly reported volumetric abnormalities in the basal ganglia, cerebellum, and prefrontal cortices. Few studies have examined the relationship between ADHD symptomatology and brain structure in population-based samples. We investigated the relationship between dimensional measures of ADHD symptomatology, brain structure, and reaction time variability—an index of lapses in attention. We also tested for associations between brain structural correlates of ADHD symptomatology and maps of dopaminergic gene expression. Methods: Psychopathology and imaging data were available for 1538 youths. Parent ratings of ADHD symptoms were obtained using the Development and Well-Being Assessment and the Strengths and Difficulties Questionnaire (SDQ). Self-reports of ADHD symptoms were assessed using the youth version of the SDQ. Reaction time variability was available in a subset of participants. For each measure, whole-brain voxelwise regressions with gray matter volume were calculated. Results: Parent ratings of ADHD symptoms (Development and Well-Being Assessment and SDQ), adolescent self-reports of ADHD symptoms on the SDQ, and reaction time variability were each negatively associated with gray matter volume in an overlapping region of the ventromedial prefrontal cortex. Maps of DRD1 and DRD2 gene expression were associated with brain structural correlates of ADHD symptomatology. Conclusions: This is the first study to reveal relationships between ventromedial prefrontal cortex structure and multi-informant measures of ADHD symptoms in a large population-based sample of adolescents. Our results indicate that ventromedial prefrontal cortex structure is a biomarker for ADHD symptomatology. These findings extend previous research implicating the default mode network and dopaminergic dysfunction in ADHD.