| |  Online-Ressource |
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| Verfasst von: | Betts, Matthew J. [VerfasserIn]  |
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| | Wichmann, Oliver [VerfasserIn] |
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| | Utz, Mathias [VerfasserIn] |
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| | André, Timon [VerfasserIn] |
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| | Gavin, Anne-Claude [VerfasserIn] |
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| | Bork, Peer [VerfasserIn] |
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| | Russell, Robert B. [VerfasserIn] |
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| Titel: | Systematic identification of phosphorylation-mediated protein interaction switches |
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| Verf.angabe: | Matthew J. Betts, Oliver Wichmann, Mathias Utz, Timon Andre, Evangelia Petsalaki, Pablo Minguez, Luca Parca, Frederick P. Roth, Anne-Claude Gavin, Peer Bork, Robert B. Russell |
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| Jahr: | 2017 |
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| Umfang: | 20 S. |
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| Fussnoten: | Published: March 27, 2017 ; Gesehen am 12.06.2018 |
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| Titel Quelle: | Enthalten in: Public Library of SciencePLoS Computational Biology |
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| Ort Quelle: | San Francisco, Calif. : Public Library of Science, 2005 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 13(2017,3) Artikel-Nummer e1005462, 20 Seiten |
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| ISSN Quelle: | 1553-7358 |
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| Abstract: | Proteomics techniques can identify thousands of phosphorylation sites in a single experiment, the majority of which are new and lack precise information about function or molecular mechanism. Here we present a fast method to predict potential phosphorylation switches by mapping phosphorylation sites to protein-protein interactions of known structure and analysing the properties of the protein interface. We predict 1024 sites that could potentially enable or disable particular interactions. We tested a selection of these switches and showed that phosphomimetic mutations indeed affect interactions. We estimate that there are likely thousands of phosphorylation mediated switches yet to be uncovered, even among existing phosphorylation datasets. The results suggest that phosphorylation sites on globular, as distinct from disordered, parts of the proteome frequently function as switches, which might be one of the ancient roles for kinase phosphorylation. |
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| DOI: | doi:10.1371/journal.pcbi.1005462 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext ; Verlag: http://dx.doi.org/10.1371/journal.pcbi.1005462 |
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| | kostenfrei: Volltext: http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005462 |
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| | DOI: https://doi.org/10.1371/journal.pcbi.1005462 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Forecasting |
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| | Glutamate |
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| | Phosphorylation |
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| | Protein interactions |
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| | Protein structure |
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| | Protein structure comparison |
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| | Protein structure prediction |
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| | Sequence alignment |
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| K10plus-PPN: | 1576283534 |
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| Verknüpfungen: | → Zeitschrift |
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Systematic identification of phosphorylation-mediated protein interaction switches / Betts, Matthew J. [VerfasserIn]; 2017 (Online-Ressource)
