Using ultrasound and palpation for predicting axillary lymph node status following neoadjuvant chemotherapy

• Verfasst von: Schwentner, Lukas Paul [VerfasserIn]
• Verfasst von: Heil, Jörg [VerfasserIn]
• Titel: Using ultrasound and palpation for predicting axillary lymph node status following neoadjuvant chemotherapy
• Titelzusatz: results from the multi-center SENTINA trial
• Verf.angabe: Lukas Schwentner, Gisela Helms, Valentina Nekljudova, Beyhan Ataseven, Ingo Bauerfeind, Nina Ditsch, Tanja Fehm, Barbara Fleige, Maik Hauschild, J. Heil, Sherko Kümmel, Anette Lebeau, Sabine Schmatloch, Peter Schrenk, Anette Staebler, Sibylle Loibl, Michael Untch, Gunter Von Minckwitz, Cornelia Liedtke, Thorsten Kühn
• Jahr: 2017
• Jahr des Originals: 2016
• Umfang: 6 S.
• Fussnoten: Available online 24 November 2016 ; Gesehen am 13.06.2018
• Titel Quelle: Enthalten in: The breast
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 1992
• Jahr Quelle: 2017
• Band/Heft Quelle: 31(2017), Seite 202-207
• ISSN Quelle: 1532-3080
• DOI: doi:10.1016/j.breast.2016.11.012
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Axillary ultrasound
• Sach-SW: Breast cancer
• Sach-SW: Neoadjuvant chemotherapy
• Sach-SW: Sentinel-node-biopsy
• K10plus-PPN: 157631636X

Abstract

Background: With the growing importance of neoadjuvant systemic therapy (NST) the assessment of post neoadjuvant axillary status is of increasing importance especially in patients who presented initially with suspicious nodes (cN1). This study aims to investigate the predictive value of palpation and axillary ultrasound of formerly cN1 patients following NST. Patients and methods: The SENTINA trial (SENTinel NeoAdjuvant) is a 4-arm prospective multicenter study designed to evaluate the role of sentinel node biopsy (SLNB) in the context of neoadjuvant systemic treatment (NST) of breast cancer patients. Results: 1240 patients from 103 institutions entered the trial. 715 (arm C n = 592; arm D n = 123) patients, who presented initially cN1 underwent clinical evaluation of lymph node status following NST. Palpation alone demonstrated a sensitivity of 8.3%, specifity of 94.8% and a negative predictive value (NPV) of 46.6%. Ultrasound alone revealed a sensitivity of 23.9%, specificity 91.7%, and a NPV of 50.3%.The investigators combined classification (palpation and ultrasound) resulted in a sensitivity of 24.4%, specificity 91.4%, and a NPV of 50.3%. Investigators classified the axilla nodes as being unsuspicious (cN0) following NST in 592/715 patients; of them 298 (50.3%) were pN0, 151 (25.5%) had 1-2 histologically involved nodes and 143 (24.2%) had >2 histologically involved nodes. Conclusion:The diagnostic accuracy of ultrasound and palpation following NST is unacceptably low and additional tools for evaluation of the axillary lymph node status following NST are urgently needed.