CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas

• Verfasst von: Sahm, Felix [VerfasserIn]
• Verfasst von: Kölsche, Christian [VerfasserIn]
• Verfasst von: Meyer, Jochen [VerfasserIn]
• Verfasst von: Pusch, Stefan [VerfasserIn]
• Verfasst von: Müller, Wolf C. [VerfasserIn]
• Verfasst von: Herold-Mende, Christel [VerfasserIn]
• Verfasst von: Deimling, Andreas von [VerfasserIn]
• Verfasst von: Hartmann, Christian [VerfasserIn]
• Titel: CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas
• Verf.angabe: Felix Sahm, Christian Koelsche, Jochen Meyer, Stefan Pusch, Kerstin Lindenberg, Wolf Mueller, Christel Herold-Mende, Andreas von Deimling, Christian Hartmann
• E-Jahr: 2012
• Jahr: June 2012
• Umfang: 7 S.
• Fussnoten: Gesehen am 13.06.2018
• Titel Quelle: Enthalten in: Acta neuropathologica
• Ort Quelle: Berlin : Springer, 1961
• Jahr Quelle: 2012
• Band/Heft Quelle: 123(2012), 6, Seite 853-860
• ISSN Quelle: 1432-0533
• DOI: doi:10.1007/s00401-012-0993-5
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1576328058

Abstract

CIC and FUBP1 mutations have recently been detected in oligodendrogliomas but not in oligoastrocytomas. However, allelic losses in the regions on chromosomal arms 19q and 1p harboring CIC and FUBP1 are a common feature of both, oligodendrogliomas and oligoastrocytomas. To resolve this discrepancy, we analyzed CIC and FUBP1 mutations in a set of primary brain tumors including 18 oligodendrogliomas and 42 oligoastrocytomas. In addition, we analyzed 10 astrocytomas and 16 glioblastomas with allelic losses on 19q as well as a set of 12 medulloblastomas for CIC mutations. CIC mutations were found in 15/18 oligodendrogliomas, 14/42 oligoastrocytomas and 3/10 preselected astrocytomas. With the exception of a single case, all CIC mutations occurred in tumors with combined 1p/19q losses. In contrast to oligodendrogliomas where CIC mutations were always detected along with 1p/19q co-deletion, CIC mutations were only found in 52 % of the 1p/19q co-deleted oligoastrocytomas. FUBP1 mutations were detected in 7/61 tumors, all presenting with CIC mutations. FUBP1 mutations appear to cluster in the DNA binding domain spanning exons 5-14. CIC and FUBP1 mutations exclusively occurred in presence of either IDH1 or IDH2 mutations. Our data confirm CIC and FUBP1 mutations in oligodendrogliomas and demonstrate the presence of these mutations in oligoastrocytomas.