Different forms of AMPA receptor mediated LTP and their correlation to the spatial working memory formation

• Verfasst von: Shimshek, Derya R. [VerfasserIn]
• Verfasst von: Koehr, Georg [VerfasserIn]
• Verfasst von: Sprengel, Rolf [VerfasserIn]
• Titel: Different forms of AMPA receptor mediated LTP and their correlation to the spatial working memory formation
• Verf.angabe: Derya R. Shimshek, Thorsten Bus, Bettina Schupp, Vidar Jensen, Verena Marx, Liliana E. Layer, Georg Köhr and Rolf Sprengel
• E-Jahr: 2017
• Jahr: 04 July 2017
• Umfang: 11 S.
• Fussnoten: Gesehen am 13.06.2018
• Titel Quelle: Enthalten in: Frontiers in molecular neuroscience
• Ort Quelle: Lausanne : Frontiers Research Foundation, 2008
• Jahr Quelle: 2017
• Band/Heft Quelle: 10(2017) Artikel-Nummer 214, 11 Seiten
• ISSN Quelle: 1662-5099
• DOI: doi:10.3389/fnmol.2017.00214
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: AMPA receptors
• Sach-SW: GluA1
• Sach-SW: GluA2
• Sach-SW: Gria1 knockout
• Sach-SW: Gria2 knockout
• Sach-SW: long-term potentiation (LTP)
• Sach-SW: spatial reference memory (SRM)
• Sach-SW: spatial working memory (SWM)
• K10plus-PPN: 1576340414

Abstract

Spatial working memory (SWM) and the classical, tetanus-induced long-term potentiation (LTP) at hippocampal CA3/CA1 synapses are dependent on L-α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPARs) containing GluA1 subunits as demonstrated by knockout mice lacking GluA1. In GluA1 knockout mice LTP and SWM deficits could be partially recovered by transgenic re-installation of full-length GluA1 in principle forebrain neurons. Here we partially restored hippocampal LTP in GluA1-deficient mice by forebrain-specific depletion of the GluA2 gene, by the activation of a hypomorphic GluA2(Q) allele and by transgenic expression of PDZ-site truncated GFP-GluA1(TG). In none of these three mouse lines, the partial LTP recovery improved the SWM performance of GluA1-deficient mice suggesting a specific function of intact GluA1/2 receptors and the GluA1 intracellular carboxyl-terminus in SWM and its associated behavior.