Precision of MRI/ultrasound-fusion biopsy in prostate cancer diagnosis

• Verfasst von: Westhoff, Niklas Christian [VerfasserIn]
• Verfasst von: Siegel, Fabian [VerfasserIn]
• Verfasst von: Hausmann, Daniel [VerfasserIn]
• Verfasst von: Polednik, Martin [VerfasserIn]
• Verfasst von: Hardenberg, Jost von [VerfasserIn]
• Verfasst von: Michel, Maurice Stephan [VerfasserIn]
• Verfasst von: Ritter, Manuel [VerfasserIn]
• Titel: Precision of MRI/ultrasound-fusion biopsy in prostate cancer diagnosis
• Titelzusatz: an ex vivo comparison of alternative biopsy techniques on prostate phantoms
• Verf.angabe: N. Westhoff, F.P. Siegel, D. Hausmann, M. Polednik, J. von Hardenberg, M.S. Michel, M. Ritter
• Jahr: 2017
• Umfang: 8 S.
• Fussnoten: First online: 09 November 2016 ; Gesehen am 14.06.2018
• Titel Quelle: Enthalten in: World journal of urology
• Ort Quelle: Berlin : Springer, 1983
• Jahr Quelle: 2017
• Band/Heft Quelle: 35(2017), 7, Seite 1015-1022
• ISSN Quelle: 1433-8726
• DOI: doi:10.1007/s00345-016-1967-3
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1576355780

Abstract

Purpose: Comparing the accuracy of MRI/ultrasound-guided target-biopsy by transrectal biopsy (TRB) with elastic versus rigid image fusion versus transperineal biopsy (TPB) with rigid image fusion in a standardized setting. Methods: Target-biopsy of six differently sized and located lesions was performed on customized CIRS 070L prostate phantoms. Lesions were only MRI-visible. After prior MRI for lesion location, one targeted biopsy per lesion was obtained by TRB with elastic image fusion with Artemis™ (Eigen, USA), TRB with rigid image fusion with real-time virtual sonography (Hitachi, Japan) and TPB with rigid image fusion with a brachytherapy approach (Elekta, Sweden), each on a phantom of 50, 100 and 150 ml prostate volume. The needle trajectories were marked by contrast agent and detected in a postinterventional MRI. Results: Overall target detection rate was 79.6% with a slight superiority for the TPB (83.3 vs. 77.8 vs. 77.8%). TRB with elastic image fusion showed the highest overall precision [median distance to lesion center 2.37 mm (0.14-4.18 mm)], independent of prostate volume. Anterior lesions were significantly more precisely hit than transitional and basal lesions (p = 0.034; p = 0.015) with comparable accuracy for TRB with elastic image fusion and TPB. In general, TRB with rigid image fusion was inferior [median 3.15 mm (0.37-10.62 mm)], particularly in small lesions. Conclusion: All biopsy techniques allow detection of clinically significant tumors with a median error of 2-3 mm. Elastic image fusion appears to be the most precise technique, independent of prostate volume, target size or location.