[18F]-Fluorodeoxyglucose-positron emission tomography in rats with prolonged cocaine self-administration suggests potential brain biomarkers for addictive behavior

• Verfasst von: Cannella, Nazzareno [VerfasserIn]
• Verfasst von: Vogler, Nils [VerfasserIn]
• Verfasst von: Wängler, Björn [VerfasserIn]
• Verfasst von: Spanagel, Rainer [VerfasserIn]
• Titel: [18F]-Fluorodeoxyglucose-positron emission tomography in rats with prolonged cocaine self-administration suggests potential brain biomarkers for addictive behavior
• Verf.angabe: Nazzareno Cannella, Alejandro Cosa-Linan, Mareike Roscher, Tatiane T. Takahashi, Nils Vogler, Björn Wängler and Rainer Spanagel
• E-Jahr: 2017
• Jahr: 01 November 2017
• Umfang: 14 S.
• Fussnoten: Gesehen am 14.06.2018
• Titel Quelle: Enthalten in: Frontiers in psychiatry
• Ort Quelle: Lausanne : Frontiers Research Foundation, 2007
• Jahr Quelle: 2017
• Band/Heft Quelle: 8(2017) Artikel-Nummer 218, 14 Seiten
• ISSN Quelle: 1664-0640
• DOI: doi:10.3389/fpsyt.2017.00218
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Addiction
• Sach-SW: biomarker
• Sach-SW: Cocaine
• Sach-SW: FDG-PET
• Sach-SW: glucose metabolism
• Sach-SW: neural activity
• Sach-SW: Psychostimulants
• Sach-SW: relapse
• K10plus-PPN: 1576356701

Abstract

The DSM5-based dimensional diagnostic approach defines substance use disorders on a continuum from recreational drug use to habitual and ultimately addicted behavior. Biomarkers that are indicative of recreational drug use and addicted behavior are lacking. We performed a translational FDG-PET study in the multi-dimensional 0/3crit model of cocaine addiction. Addict-like (3crit) and non-addict-like (0crit) rats, which shared identical life conditions and levels of cocaine self-administration, were acquired for FDG-PET under baseline conditions and following cocaine and yohimbine challenges. Compared to cocaine-naïve control rats, 0crit animals showed higher glucose uptake in the caudate putamen and medial prefrontal cortex respect to naïve controls. 3-crit animals did not show this adaptive higher glucose utilization, but had lower uptake in several cortical areas. Both cocaine and yohimbine challenges affected glucose uptake in control rats in several brain sites, but not in 0crit and 3crit rats, indicating that impaired glucose mobilization in response to these challenges is not specifically associated with addictive behavior. Compared to 0crit, 3crit rats showed higher reinstatement responses, which were negatively associated with glucose uptake in the ventral tegmental area. Data indicate that cocaine non-addict- and addict-like phenotypes are associated with several potential biomarkers. Specifically, we propose that increased glucose uptake in the caudate putamen and medial prefrontal cortex is a function of controlled drug use, whereas a loss of striatal and prefrontal metabolic activity and reduced uptake in cortical areas are indicative of addictive behavior.