Sodium MRI of T1 high signal intensity in the dentate nucleus due to gadolinium deposition in multiple sclerosis

• Verfasst von: Eisele, Philipp [VerfasserIn]
• Verfasst von: Szabo, Kristina [VerfasserIn]
• Verfasst von: Meyer, Melissa [VerfasserIn]
• Verfasst von: Zöllner, Frank G. [VerfasserIn]
• Verfasst von: Schad, Lothar R. [VerfasserIn]
• Verfasst von: Schönberg, Stefan [VerfasserIn]
• Verfasst von: Gass, Achim [VerfasserIn]
• Titel: Sodium MRI of T1 high signal intensity in the dentate nucleus due to gadolinium deposition in multiple sclerosis
• Verf.angabe: Philipp Eisele, Simon Konstandin, Kristina Szabo, Melissa Ong, Frank Zöllner, Lothar R. Schad, Stefan O. Schoenberg, Achim Gass
• Jahr: 2017
• Umfang: 4 S.
• Fussnoten: First published: 01 June 2017 ; Gesehen am 14.06.2018
• Titel Quelle: Enthalten in: Journal of neuroimaging
• Ort Quelle: Berlin [u.a.] : Wiley-Blackwell, 1991
• Jahr Quelle: 2017
• Band/Heft Quelle: 27(2017), 4, Seite 372-375
• ISSN Quelle: 1552-6569
• DOI: doi:10.1111/jon.12448
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: MRI
• Sach-SW: 23Na
• Sach-SW: dentate nucleus
• Sach-SW: gadolinium
• Sach-SW: Multiple sclerosis
• Sach-SW: sodium
• K10plus-PPN: 1576380238

Abstract

Background and purpose: Recently, several studies reported increased signal intensity (SI) of the dentate nucleus (DN) on unenhanced T1-weighted magnetic resonance imaging (MRI) as a possible consequence of multiple applications of gadolinium-based contrast agents. The aim of this study was to investigate with sodium (23Na) MRI possible tissue abnormalities of the DN in multiple sclerosis (MS) patients. Methods: Sodium and conventional MRI were performed on a clinical 3T scanner. Total sodium concentrations (TSCs) of the DN, as well as DN-to-pons and DN-to-cerebellum SI ratios on unenhanced T1-weighted MRI were calculated. Results: A total of 18 subjects (6/18 normal controls, 12/18 MS patients [6/12 with T1 hyperintense DN]) were investigated. There was no significant difference of TSC values of the DN in MS patients with a T1-hyperintense DN (33.70 ± 2.14 mM) compared to MS patients without those signal abnormalities (33.29 ± 1.67 mM; P = .67) or to healthy controls (33.14 ± 1.12; P = .32). Conclusions: Normal sodium signal in the T1-hyperintense DN in MS patients may point to relative tissue integrity despite gadolinium deposition in this area.